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    Glossary PI3K inhibitor

    blocks enzyme activity involved in cell growth and survival

    A PI3K inhibitor, also known as a phosphoinositide 3-kinase inhibitor, is a type of drug that blocks the activity of the PI3K enzyme. This enzyme is involved in various cellular functions, including growth, proliferation, and survival. By inhibiting PI3K, these drugs can help treat certain cancers and other diseases where PI3K is abnormally active.

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    1. Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition Discovery Medicine · 2025 · 3 citations
    2. The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation Experimental Dermatology · 2015 · 15 citations
    3. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    4. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    5. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats Scientific reports · 2018 · 28 citations
    6. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells Annals of Medicine · 2025
    7. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    8. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    9. EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals Developmental Biology · 2012 · 53 citations
    10. Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique NPJ breast cancer · 2024 · 1 citations
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