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    Glossary PI3K inhibitor

    blocks enzyme activity involved in cell growth and survival

    A PI3K inhibitor, also known as a phosphoinositide 3-kinase inhibitor, is a type of drug that blocks the activity of the PI3K enzyme. This enzyme is involved in various cellular functions, including growth, proliferation, and survival. By inhibiting PI3K, these drugs can help treat certain cancers and other diseases where PI3K is abnormally active.

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    Research 30 of 1000+

    1. Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition Discovery Medicine · 2025 · 3 citations
    2. The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation Experimental Dermatology · 2015 · 15 citations
    3. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    4. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    5. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats Scientific reports · 2018 · 28 citations
    6. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells Annals of Medicine · 2025
    7. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    8. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    9. EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals Developmental Biology · 2012 · 53 citations
    10. Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique NPJ breast cancer · 2024 · 1 citations
    11. An overview of animal models induced by glucocorticoids Physiology and Pharmacology · 2023
    12. The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19 Frontiers in Pharmacology · 2022 · 15 citations
    13. Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives International Journal of Molecular Sciences · 2024 · 9 citations
    14. 691 Topical curcumin promotes induction of the murine hair cycle 2016 · 3 citations
    15. NF-κB in biology and targeted therapy: new insights and translational implications Signal transduction and targeted therapy · 2024 · 1 citations
    16. New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & therapeutics Frontiers in Oncology · 2023
    17. l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase 2009 · 34 citations
    18. Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation Molecular cancer therapeutics · 2013 · 23 citations
    19. Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers Experimental dermatology · 2022 · 7 citations
    20. Cutaneous adverse effects of targeted therapies Journal of the American Academy of Dermatology · 2015 · 149 citations
    21. Finasteride as a potential tool to improve Mesenchymal stem cell transplantation for myocardial infarction Medical Hypotheses · 2012 · 4 citations
    22. Data Sheet 2_Quercetin promotes production of secondary hair follicle stem cells in cashmere goat: a mechanistic study.zip OPAL (Open@LaTrobe) (La Trobe University) · 2025
    23. Is knowledge about the genetic and epigenetic alterations in melanoma a basis for targeted therapy? Experimental Dermatology · 2006
    24. Role of phosphatidylinositol 3‐kinase signaling pathway in radiation‐induced liver injury The Kaohsiung Journal of Medical Sciences · 2020 · 6 citations
    25. LncRNA RP11-818O24.3 regulates proliferation and differentiation of hair follicle stem cells by targeting FGF2/PI3K/AKT pathway PLoS ONE · 2025 · 1 citations
    26. Targeting the Hypoxic Microenvironment in Cutaneous Chronic Graft-Versus-Host Disease through PI3Kδ Inhibition Blood · 2024 · 1 citations
    27. Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model Journal of Biomedical Nanotechnology · 2022
    28. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    29. 1372 Modulation of YBX1 phosphorylation determines epidermal stem cell function Journal of Investigative Dermatology · 2023
    30. Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice Hippocampus · 2009 · 85 citations