This study utilized polarized light microscopy to examine hair shafts in ten children with rare genetic disorders, such as Netherton syndrome and ectodermal dysplasia, providing valuable diagnostic insights into hair thickness, composition, and structural irregularities associated with these conditions.
59 citations
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March 2020 in “Journal of Biomedical Science” This study explored the complex roles of niche cells in regulating hair follicle stem cells, identifying specific cell functions such as signaling, sensing, and relaying messages, which could provide insights into treating hair loss conditions like androgenetic alopecia and alopecia areata.
5 citations
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June 2019 in “British Journal of Dermatology” No results are provided in this article as it lacks an available abstract, making it unclear what effects apremilast and tofacitinib have in a humanized mouse model of alopecia areata.
2 citations
,
March 2020 in “International Journal of Molecular Sciences” This article reviews advanced strategies for enhancing drug delivery to cutaneous stem cells to improve treatment for skin conditions and reports no new experimental findings.
2 citations
,
November 1987 in “Archives of Dermatology” This study found that minoxidil was released 50% less from creams than from lotions, with a similar release profile across different lotion formulations, suggesting a specific vehicle composition for topical use.
January 2026 in “Frontiers in Materials” This review discusses the potential of metal organic frameworks for drug delivery in wound treatment, highlighting their unique properties and recent research advancements, but reports no new clinical results.
August 2025 in “MedScien” This study explores the design of responsive drug carriers based on the tumor microenvironment to improve targeting and reduce side effects in cancer treatment, using a model of delivering curcumin with a responsive polymer carrier and evaluating potential errors due to cancer cell heterogeneity.
March 2021 in “Indian Journal of Case Reports” This case report describes a young adult female with late-stage Vogt-Koyanagi-Harada disease featuring panuveitis, retinal detachment, hearing loss, alopecia, and vitiligo, who was successfully treated in a hospital.
This research concluded that the novel hydrogel PlacMA, derived from human placenta and curable by visible light, shows promise for cell culture and tissue engineering applications due to its tunable properties.
260 citations
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January 2019 in “Pharmaceutics” This study highlights that niosomes, or non-ionic surfactant based vesicles, offer an advantageous drug delivery system due to their stability, cost-effectiveness, and ability to enhance drug bioavailability and targeting efficiency for various therapeutic agents.
127 citations
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January 2013 in “PLOS ONE” This study found that feeding aged mice a probiotic yogurt induced changes leading to thicker, healthier fur, suggesting a bacteria-triggered interleukin-10-dependent mechanism that mimics signs of youth and reproductive fitness.
53 citations
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April 2014 in “Experimental Dermatology” In this study, ectopic Wnt10b-mediated β-catenin activation in hair follicles resulted in larger regenerating anagen hair structures, an effect modulated by the Wnt inhibitor DKK1.
23 citations
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June 2012 in “PLOS ONE” This study found that KLF4 expression in mouse hair follicle stem cells is important for effective cutaneous wound healing, with its knockdown leading to reduced stem cell populations and delayed healing.
22 citations
,
August 2006 in “Critical Reviews in Plant Sciences” The tropical legume Sesbania rostrata can form nodules in waterlogged conditions using a different method that involves plant hormones and specific genes.
19 citations
,
January 2015 in “Scientific Reports” This study found that the GPR39 receptor plays a novel role in accelerating wound healing in mouse skin, although it is not essential for skin development or homeostasis.
18 citations
,
September 2011 in “Livestock science” This study found that maternal Nano-Se supplementation in cashmere goats improved antioxidant status and promoted secondary hair follicle development in fetuses at 110 days.
17 citations
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June 2020 in “Animals” This study identified differentially expressed mRNAs and lncRNAs in Hu sheep hair follicles, suggesting certain genes and pathways are involved in the development of wool curvature patterns.
17 citations
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June 2019 in “BMC genomics” This study cataloged several long non-coding RNAs and microRNAs in cashmere goat dermal papilla cells, suggesting these non-coding RNAs may play a role in hair follicle stem cell activation and hair growth.
16 citations
,
April 2022 in “PLoS ONE” This study identified a set of tumour-suppressive microRNAs (miRNAs), termed 'normomiRs', that are highly expressed in normal tissues but low in tumors, with miR-206 and miR-381 showing significant in vitro cancer inhibition, highlighting their potential for miRNA-replacement therapies across multiple cancer types.
14 citations
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January 2008 in “Gene therapy” Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.
10 citations
,
January 2024 in “Polymer Chemistry” This review discusses the design and advances of lipid–polymer hybrid nanoparticles as promising delivery systems for genome editing strategies, highlighting their potential in biomedical applications.
9 citations
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November 2012 in “Biomolecules & therapeutics” This study found that diphlorethohydroxycarmalol significantly increased prostaglandin $E_2$ synthesis in HaCaT human keratinocytes by upregulating COX-1 and COX-2 expression, suggesting potential benefits from elevated $PGE_2$ production.
8 citations
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May 2021 in “Bioengineering & translational medicine” This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.
7 citations
,
February 2019 in “Journal of pharmacological sciences” This study found that Bazhengsan significantly reduced inflammation and hyperplasia in male rats with nonbacterial prostatitis, indicating potential as a treatment for chronic prostatitis.
6 citations
,
May 1997 in “Journal of Dermatological Science” This study found that a gene from hamster flank organs is indirectly regulated by androgens, despite lacking direct androgen responsive elements, indicating involvement of androgen-dependent transcription factors.
4 citations
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February 2021 in “Nano select” This review discusses the role and therapeutic potential of mesenchymal cell-derived exosomes in organ development and disease treatment, highlighting their application in cell-free therapeutic strategies and current challenges faced in their use.
1 citations
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December 2022 in “Biomolecules & therapeutics” This study found that a long-term astrocyte culture model can effectively study astrocyte senescence and suggests minoxidil as a potential candidate to regulate brain aging by normalizing dysregulated gene expression in aged astrocytes.
1 citations
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October 1996 in “Journal of Cutaneous Medicine and Surgery” This review discusses the advancements needed for gene therapy to become commonly used in dermatology and reports no new clinical results.
September 2025 in “Animal Bioscience” This study found that triglyceride and energy metabolic pathways are crucial factors influencing wool fiber diameter in fine-wool Alpine Merino sheep, providing insights for enhancing wool quality.
August 2025 in “Animal Bioscience” In this study, researchers examined the methylation patterns in the skin tissues of Alpine Merino sheep with varying wool fiber diameters, finding that specific methylated RNAs linked to the Wnt, Notch, and TGF-ẞ signaling pathways may influence fiber diameter and potentially improve wool quality.