Anti-Inflammatory and Anti-Hyperplastic Effect of Bazhengsan in a Male Rat Model of Chronic Nonbacterial Prostatitis

    February 2019 in “ Journal of pharmacological sciences ”
    Youyi Xiong, Lili Zhou, Xingtao Qiu, Chenggui Miao
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    Studysummary This study found that Bazhengsan significantly reduced inflammation and hyperplasia in male rats with nonbacterial prostatitis, indicating potential as a treatment for chronic prostatitis. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the effects of Bazhengsan on chronic nonbacterial prostatitis in male rats. Prostatitis was induced using 17-beta-estradiol and dihydrotestosterone, and Bazhengsan treatment was administered. After 8 weeks, results showed that Bazhengsan significantly reduced inflammation and collagen deposition in prostate tissues, decreased levels of PVC, IL-6, IL-8, IL-17, MCP-1, VCAM-1, FGF-2, VLA-4, CCL-2, and FGFR-1, and increased levels of LCD and SIg-A compared to the model group. These findings suggested that Bazhengsan had significant anti-inflammatory and anti-hyperplastic effects, indicating its potential as a therapeutic agent for chronic prostatitis.
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