Study on the Mechanism That SNPs Related to Sex Hormone Metabolism Regulate the Imbalance of Sex Hormones and Lead to BPH in Rats

This study investigated the role of sex hormone imbalances and genetic polymorphisms in the development of benign prostatic hyperplasia (BPH) in rats. Using 264 male Sprague–Dawley rats, the research evaluated the effects of finasteride and anastrozole, both individually and in combination, on prostate health. The combination treatment was more effective than either drug alone in reducing prostate weight, volume, and index, and in modulating hormone levels. Significant correlations were found between specific SNPs in the CYP17A1 and CYP19A1 genes and BPH. The study concludes that combined therapy with finasteride and anastrozole can effectively prevent and treat BPH, and that sex hormone imbalances and genetic factors play crucial roles in its pathogenesis.