research Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles
Certain genetic variants linked to immune response increase the risk of alopecia areata in Taiwanese people.
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research The Immune Functions of Keratinocytes in Skin Wound Healing
Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
research T-Cell Induced-Self MHC Class I/Peptide Complexes May Enable De Novo Tolerance Induction to Neo-Antigens Occurring Outside of the Thymus
Hair follicles may help teach the immune system to tolerate new self-antigens, but this can sometimes cause hair loss.
research Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies
New insights into cell communication in psoriasis suggest innovative drug treatments.
research SnapshotDx Quiz: February 2018
Blocking certain pathways with kinase inhibitors may help treat cutaneous lupus erythematosus.
research The Pathogenesis of Alopecia Areata in Rodent Models
Alopecia Areata is an autoimmune disease affecting hair follicles, influenced by genetic and environmental factors, with rodent models being essential for research.
research Alopecia Areata: Animal Models
Alopecia areata is influenced by genetics and immune system factors, and better understanding could improve treatments.
research Skin Commensal Antigens: Taking the Road Less Traveled
Skin bacteria can help wound healing by activating certain immune cells.
research Quiescent Tissue Stem Cells Evade Immune Surveillance
Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.
research Epidermal Growth Factor Receptor Protects From Immune Privilege Collapse and Scarring Hair Follicle Destruction
Blocking EGFR can lead to hair loss due to inflammation and stem cell damage.
research Frontal Fibrosing Alopecia Is Associated With Dysregulation of Cholesterol Biosynthesis Pathways, Fibrosis, and Mast Cells
Frontal Fibrosing Alopecia involves disrupted cholesterol pathways, fibrosis, and increased mast cells.
research Dandruff Lesional Scalp Skin Exhibits Epidermal T Cell Infiltration and a Weakened Hair Follicle Immune Privilege
Dandruff is linked to increased T cells and weakened immune protection in hair follicles.
research Epidermal Growth Factor Receptor as a Key Regulator of Immune Privilege
EGFR is crucial for preventing hair follicle inflammation and hair loss.
research Allogeneic Hair Transplantation with Enhanced Survival by Anti-ICAM-1 Antibody with Short-Term Rapamycin Treatment in Nonhuman Primates
Using an anti-ICAM-1 antibody with rapamycin improves hair transplant survival in monkeys.
research Autoantigen Screening in C3H/HeJ Mouse Model of Alopecia Areata Revealed High Antigenicity of Melanocyte-Associated Antigen Epitopes
Melanocyte-associated antigens may play a key role in alopecia areata and could be targets for new treatments.
research Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice
Nanoparticles can deliver vaccines through hair follicles, triggering immune responses and providing protection.
research Immunization by Application of DNA Vaccine onto a Skin Area Where the Hair Follicles Have Been Induced into Anagen-Onset Stage
Applying a DNA vaccine to skin with active hair growth boosts immune response and protection against anthrax in mice.
research Antigen Presenting Cells in the Skin of a Patient with Hair Loss and Systemic Lupus Erythematosus
Antigen presenting cells around hair follicles are crucial in SLE-related hair loss.
research Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege
The nail matrix has a reduced immune response, protecting it from autoimmunity.
research Down-Ranking the Threat of HSV-1: RANKL Upregulates MHC Class I Restricted Anti-Viral Immunity in Herpes Simplex Virus Infection
RANKL improves the immune response against herpes simplex virus by enhancing T cell activation and could help develop better treatments or vaccines.
research Cell Surface B2m-Free Human Leukocyte Antigen Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?
B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.
research Sarcoidosis: Are There Differences in Your Skin of Color Patients?
Sarcoidosis is more common and severe in Black patients than in Caucasians, requiring early diagnosis and treatment.
research Trichodysplasia of Immunosuppression Treated with Oral Valganciclovir
Oral valganciclovir improved a patient's skin condition caused by immunosuppression.
research The Influence of Interferon on Healthy and Diseased Skin
Type I interferons play a key role in the development of various skin diseases.
research Solitary Fixed Drug Eruption Caused by Finasteride
Finasteride can cause a unique skin reaction on the penile shaft.
research Updates in the Pathogenesis of Alopecia Areata
Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.
research Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata
Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.
research Gene-Environment Interaction Between CYP1B1 and Oral Contraception on Frontal Fibrosing Alopecia
Oral contraceptive use may increase the risk of frontal fibrosing alopecia in women with a specific CYP1B1 gene variant.
research The Coenzyme A Precursor Pantethine Enhances Antitumor Immunity in Sarcoma
Pantethine may boost the immune system's ability to fight sarcoma.
research Immune Privilege and Alopecia Areata
Restoring immune privilege in hair follicles could help treat certain types of hair loss.