Autoantigen Screening in C3H/HeJ Mouse Model of Alopecia Areata Revealed High Antigenicity of Melanocyte-Associated Antigen Epitopes

April 2019 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

E. Wang, S. Erjavec, Christina I. Tejeda, Angela M. Christiano

alopecia areata melanocyte-associated antigens CD8 T cell anagen stage melanosomal membrane glycoprotein OA1 SLC24A5 SLC45A2 antigen-specific tolerogenic therapies AA CD8 T cells anagen phase melanosomal glycoprotein OA1 protein SLC24A5 protein SLC45A2 protein tolerogenic therapies

Studysummary This study found that anagen stage protein homogenates and specific epitopes from melanogenesis proteins activated CD8 T cells, suggesting alopecia areata is an anagen-specific disease.

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