January 2026 in “Experimental Dermatology” This review discusses the role of keratinocytes in hidradenitis suppurativa, highlighting their genetic and metabolic influences on disease progression without presenting new clinical results.
April 2018 in “Journal of Investigative Dermatology” This study found that acne lesions and nonlesional skin in mild-to-moderate acne patients showed significant Th17-skewing and increased antimicrobials, suggesting systemic targets like IL-17/IL-23/IL-36 could be therapeutic.
19 citations
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June 1999 in “Steroids” This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.
144 citations
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November 2020 in “Frontiers in immunology” This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.
104 citations
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January 2016 in “Food & Function” This review found that olive oil phenols may have anti-cancer properties in animal models and some human studies, but further research is needed to confirm these effects in humans.
December 2023 in “International journal of multidisciplinary research and analysis” In this study, topical administration of secretome hypoxia mesenchymal stem cells gel increased IL-10 and decreased TNF-α gene expression in a fluconazole-induced alopecia-like model in rats, with the 40 μL dose having the most significant effect.
April 2018 in “Journal of Investigative Dermatology” In this study, researchers reported that IL-17C plays a key pro-inflammatory role in human skin diseases and may be a promising therapeutic target for inflammatory skin conditions.
September 2018 in “International journal of biosciences” This study found that women with both PCOS and gingivitis had significantly higher levels of AMH in their saliva compared to those with only PCOS, gingivitis, or neither condition.
176 citations
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August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.
20 citations
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December 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” In this study, ustekinumab did not promote hair regrowth in human patients with alopecia areata or prevent disease development in an AA mouse model, suggesting limited efficacy for this treatment.
August 2024 in “Qucosa (Saxon State and University Library Dresden)” In this study on mice, researchers observed that dermal white adipose tissue (dWAT) plays a key role in regulating skin inflammation and tissue repair; however, reduced expression of certain cytokines in obese mice may hinder these processes, indicating potential metabolic disruptions in dWAT during inflammation.
5 citations
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June 2022 in “Frontiers in immunology” This study observed that expanding regulatory T cells in the skin of mice with alopecia areata did not reverse the condition, indicating that additional immunotherapy may be necessary.
July 2024 in “Egyptian Journal of Medical Human Genetics” In this case-control study, the researchers found no significant association between IL-4 VNTR intron 3 and TNF-α (rs1799964) gene polymorphisms and alopecia areata susceptibility among the Egyptian population.
December 2023 in “Research Square (Research Square)” This study found that IL-4 VNTR intron 3 and TNF-α (rs1799964) gene polymorphisms do not have a significant association with alopecia areata susceptibility in the Egyptian population.
51 citations
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May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology” This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.
45 citations
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August 2019 in “Dermatologic Therapy” This review discusses the physiopathology of androgenetic alopecia and evaluates various traditional and emerging treatments, reporting no new clinical results but highlighting the need for enhanced treatment strategies.
1 citations
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April 2018 in “Journal of Investigative Dermatology” In this study, OEA was found to significantly enhance sebaceous lipogenesis and potentially reduce inflammation in human sebocytes, suggesting it as a promising candidate for treating skin dryness.
April 2018 in “Journal of Investigative Dermatology” The researchers reported that nicotinic acid normalized excessive sebaceous lipogenesis without affecting basal lipogenesis and suggested potential anti-acne benefits.
15 citations
,
March 2021 in “Journal of clinical medicine” This review discusses common skin eruptions caused by biologics in treating inflammatory bowel disease and proposes tailored therapeutic approaches for managing these adverse reactions.
October 2025 in “Editora Pasteur eBooks” The abstract discusses the multidisciplinary nature and advancement of dermatology and aesthetic procedures within the health sciences, emphasizing the integration of diagnostic, corrective, preventive, and therapeutic approaches, but does not provide specific study results.
44 citations
,
September 2014 in “Cell Death & Differentiation” This review discusses the role of tumor suppressors in controlling tumor-associated inflammation and suggests that targeting this inflammation may counteract the effects of tumor suppressor loss.
295 citations
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March 2016 in “Life Sciences” This review discusses the links between particulate matter exposure and skin diseases, highlighting oxidative stress and inflammation as key mechanisms; it reports no new clinical results.
21 citations
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March 2019 in “Critical Reviews in Clinical Laboratory Sciences” This review discusses the role of the androgen receptor in breast cancer diagnosis and treatment, and notes a lack of new research results on its therapeutic potential.
9 citations
,
June 2014 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” Blood AMH levels are higher in women with PCOS than in those with other similar conditions.
47 citations
,
March 2019 in “Journal of immunology research” This review discusses the effects of valproic acid on immune cell activation and gene expression, potentially influencing infection outcomes and suggesting its promise for autoimmune and hypersensitivity condition management.
2 citations
,
February 2018 in “InTech eBooks” This article discusses adverse immune-mediated skin reactions associated with TNF-alpha inhibitors, highlighting paradoxical reactions such as psoriasis that occur despite being treated with medications intended to alleviate the condition.
2 citations
,
September 2015 in “Clínica e Investigación en Arteriosclerosis” This review discusses the association between certain dermatological diseases and increased cardiovascular risk, highlighting the need for clinicians to address cardiovascular risk factors in these patients.
March 2026 in “Frontiers in Immunology” This review discusses the multifaceted roles of regulatory T cells in cutaneous wound healing and highlights potential therapeutic strategies targeting these cells to enhance wound repair in chronic and diabetic wounds, but reports no new clinical results.
36 citations
,
December 2015 in “Drugs” This review summarizes various drug treatments for hidradenitis suppurativa, noting their effectiveness, side effects, and high recurrence rates, but reports no new clinical findings.
3 citations
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May 2018 in “Experimental Dermatology” In this study, the researchers reported that patient impacts and symptoms of hidradenitis suppurativa, as assessed by HSIA and HSSA measures, are associated with clinical characteristics such as the number of abscesses and inflammatory nodules.