The Evaluation of IL-4 Intron 3 VNTR and TNF-α (rs1799964) Gene Polymorphisms in Egyptian Patients with Alopecia Areata: A Case-Control Study

This case-control study investigated the potential association between IL-4 intron 3 VNTR and TNF-α (rs1799964) gene polymorphisms and Alopecia Areata (AA) in 79 Egyptian patients and 156 healthy controls. Using PCR and PCR-RFLP techniques, the study found no statistically significant differences in the polymorphisms between patients and controls, nor any correlation with clinical and demographic data. The results suggest that these specific gene polymorphisms are not linked to AA susceptibility in the Egyptian population.