Immunomodulatory Roles of Regulatory T Cells in Cutaneous Wound Healing: Mechanisms and Therapeutic Opportunities

    March 2026 in “ Frontiers in Immunology ”
    Samuel Emeka Peter, Farooq RIAZ, Yikui Li … Feng Pan
    Studysummary This review discusses the multifaceted roles of regulatory T cells in cutaneous wound healing and highlights potential therapeutic strategies targeting these cells to enhance wound repair in chronic and diabetic wounds, but reports no new clinical results.
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    Research cited in this study 13

    1. Stem Cell-Derived Extracellular Vesicles: Promising Therapeutic Opportunities for Diabetic Wound Healing International Journal of Nanomedicine · 2024
    2. CD80 on Skin Stem Cells Promotes Local Expansion of Regulatory T Cells Upon Injury to Orchestrate Repair Within an Inflammatory Environment Immunity · 2024
    3. Treg–Tissue Cell Interactions in Repair and Regeneration ˜The œJournal of experimental medicine/˜The œjournal of experimental medicine · 2024
    4. Cellular Therapeutics and Immunotherapies in Wound Healing – On the Pulse of Time? Military Medical Research/Military medical research · 2024
    5. An ROS-Scavenging Treg-Recruiting Hydrogel Patch for Diabetic Wound Healing Advanced Functional Materials · 2024
    6. Regulatory T Cells in Skin Regeneration and Wound Healing Military Medical Research/Military medical research · 2023
    7. Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration Nature Communications · 2023
    8. Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models International Journal of Molecular Sciences · 2022
    9. Wound Healing: Cellular Mechanisms and Pathological Outcomes Open Biology · 2020
    10. The Dynamics of the Skin’s Immune System International Journal of Molecular Sciences · 2019
    11. Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration Frontiers in Immunology · 2018
    12. Regulatory T Cells Are Required for Normal and Activin-Promoted Wound Repair in Mice European Journal of Immunology · 2018
    13. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017