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    Glossary Androgen Pathway

    process by which androgens influence cellular functions and characteristics

    The androgen pathway involves the process by which androgens, a group of hormones like testosterone, interact with cells in the body. These hormones bind to androgen receptors, influencing various biological functions such as hair growth, muscle development, and the regulation of male characteristics. In the context of hair, this pathway can affect hair follicle health and is often linked to conditions like androgenetic alopecia (pattern baldness).

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    1. Cross-kingdom delivery and putative gene modulation of androgen pathways by plant-derived exosome-like nanoparticles from polygoni multiflori radix promotes hair growth via miRNA cargo Pharmacological Research · 2025
    2. Alternative androgen pathways WikiJournal of Medicine · 2023
    3. 896 Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line Journal of Investigative Dermatology · 2019
    4. Androgen biosynthetic pathways in the human prostate 2008 · 160 citations
    5. 592 Cross-interactions of BMP and WNT signaling pathways attenuate androgen effect on HFSC differentiation Journal of Investigative Dermatology · 2019
    6. Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia Dermatologic Surgery · 2019 · 11 citations
    7. Pharmacogenetics of the Androgen Metabolic Pathway 2010
    8. Deciphering the Role of Androgen in the Dermatologic Manifestations of Polycystic Ovary Syndrome Patients: A State-of-the-Art Review Diagnostics · 2024 · 10 citations
    9. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020 · 139 citations
    10. Defects in Androgen Biosynthesis Causing 46,XY Disorders of Sexual Development Seminars in reproductive medicine · 2012 · 46 citations
    11. Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep Cell Death and Disease · 2020 · 23 citations
    12. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis Carcinogenesis · 2003 · 138 citations
    13. Androgens and androgen receptor action in skin and hair follicles Molecular and Cellular Endocrinology · 2017 · 100 citations
    14. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia Molecular and Cellular Endocrinology · 2016 · 47 citations
    15. In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach Journal of Investigative Dermatology Symposium Proceedings · 1999 · 30 citations
    16. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018 · 18 citations
    17. Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg–like Cells, and Common EGFR Somatic Mutations The American Journal of Surgical Pathology · 2021 · 4 citations
    18. The AR/miR-221/IGF-1 pathway mediates the pathogenesis of androgenetic alopecia International Journal of Biological Sciences · 2023 · 2 citations
    19. The Hair Follicle and Hair Loss: A Review of DHT, Inflammation, Oxidative Stress, Vascular Signalling and the Biological Pathways Behind Hair Growth Zenodo (CERN European Organization for Nuclear Research) · 2026
    20. Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome Frontiers in endocrinology · 2023
    21. 0980 Tanshinone capsule enhances hair follicle regeneration in a mouse model of androgenetic alopecia via IGF1 and Wnt/β-catenin pathway Journal of Investigative Dermatology · 2026
    22. Regulatory pathways implicated in male androgenetic alopecia pathogenesis British Journal of Dermatology · 2017
    23. Ar/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia Social Science Research Network · 2022
    24. COVID‐19, androgens, and androgenic alopecia Dermatological reviews · 2020 · 6 citations
    25. Female pattern hair loss possibly caused by tamoxifen: Androgen receptor expression in the outer root sheath in the affected area Journal of Dermatology · 2012 · 5 citations
    26. Revising the role of the androgen receptor in breast cancer Journal of Molecular Endocrinology · 2014 · 68 citations
    27. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats Scientific reports · 2018 · 28 citations
    28. Targets to treat androgen excess in polycystic ovary syndrome Expert Opinion on Therapeutic Targets · 2015 · 14 citations
    29. The Rise in Adrenal Androgen Biosynthesis: Adrenarche Seminars in Reproductive Medicine · 2004 · 173 citations
    30. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations