Effects of Doxazosin and Combined Doxazosin Plus Finasteride on Parenchyma-Stroma Interaction in Rat Prostate

August 2021

Luiz Antonio Justulin

doxazosin finasteride testosterone dihydrotestosterone TGF-β1 MMP-2 TIMP-1 TIMP-2 MMP-9 androgen pathways Propecia

TLDR The combined treatment of Finasteride and Doxazosin affects prostate tissue by reducing cell growth and altering hormone levels.

The study investigated the effects of combined Finasteride and Doxazosin treatment on prostate tissue in adult Wistar rats. The treatment led to a transient increase in plasma testosterone and a permanent reduction in dihydrotestosterone. It reduced ventral prostate and epithelial cell proliferation, increased stromal collagen fibers, and epithelial cell apoptosis. Additionally, it elevated TGF-β1 immunoreaction in both epithelium and stroma, decreased mRNA expressions for MMP-2, TIMP-1, and TIMP-2, and altered MMP-2 and MMP-9 activities. These findings suggest that the combination therapy affects epithelial cell behavior and MMP activity, potentially through TGF-β1 and androgen pathways, enhancing the understanding of its molecular mechanisms and clinical implications.

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