Effects of Doxazosin and Combined Doxazosin Plus Finasteride on Parenchyma-Stroma Interaction in Rat Prostate

August 2021

Luiz Antonio Justulin

doxazosin finasteride testosterone dihydrotestosterone TGF-β1 MMP-2 TIMP-1 TIMP-2 MMP-9 androgen pathways Propecia

TLDR The combined treatment of Finasteride and Doxazosin affects prostate tissue by reducing cell growth and altering hormone levels.

The study investigated the effects of combined Finasteride and Doxazosin treatment on prostate tissue in adult Wistar rats. The treatment led to a transient increase in plasma testosterone and a permanent reduction in dihydrotestosterone. It reduced ventral prostate and epithelial cell proliferation, increased stromal collagen fibers, and epithelial cell apoptosis. Additionally, it elevated TGF-β1 immunoreaction in both epithelium and stroma, decreased mRNA expressions for MMP-2, TIMP-1, and TIMP-2, and altered MMP-2 and MMP-9 activities. These findings suggest that the combination therapy affects epithelial cell behavior and MMP activity, potentially through TGF-β1 and androgen pathways, enhancing the understanding of its molecular mechanisms and clinical implications.

View this study on doi.org →

Discuss this study in the Community →

Similar Research

5 / 187 results

research Hormonal Manipulation of Benign Prostatic Hyperplasia

18 citations, November 2012 in “Current opinion in urology”

Finasteride and dutasteride are equally effective and safe for treating benign prostatic hyperplasia.

Is COVID-19 a Risk Factor for Progression of Benign Prostatic Hyperplasia and Exacerbation of Its Related Symptoms?: A Systematic Review

research Is COVID-19 a Risk Factor for Progression of Benign Prostatic Hyperplasia and Exacerbation of Its Related Symptoms?: A Systematic Review

21 citations, May 2021 in “Prostate Cancer and Prostatic Diseases”

COVID-19 might worsen symptoms and progression of benign prostatic hyperplasia, possibly due to inflammation and metabolic disturbances in the prostate gland. More research is needed to confirm this.

research Dihydroartemisinin Attenuates Benign Prostatic Hyperplasia in Rats by Inhibiting Prostatic Epithelial Cell Proliferation

4 citations, August 2021 in “Annals of Translational Medicine”

Dihydroartemisinin helps reduce prostate enlargement in rats by stopping the growth of prostate cells.

research What Do We Know About Phytotherapy of Benign Prostatic Hyperplasia?

67 citations, February 2015 in “Life Sciences”

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Post-Finasteride Syndrome: When Will We Get the Courage to Fight the Dictating Pharma Industry Despite Awareness of Sexual, Neurological, and Metabolic Side Effects in Young Men for Over a Decade

research Post-Finasteride Syndrome: When Will We Get the Courage to Fight the Dictating Pharma Industry Despite Awareness of Sexual, Neurological, and Metabolic Side Effects in Young Men for Over a Decade

January 2020 in “Archives of urology”

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.