211 citations,
November 2018 in “Nature Cell Biology” Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.
106 citations,
October 2016 in “Cell Stem Cell” PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
93 citations,
February 2015 in “Journal of Investigative Dermatology” Oxidative stress affects hair loss in men with androgenetic alopecia.
76 citations,
June 2015 in “Journal of biomedical science” Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.
72 citations,
April 2008 in “Organogenesis” Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.
67 citations,
August 2013 in “International Journal of Cosmetic Science” Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.
36 citations,
April 2018 in “Journal of Investigative Dermatology” Macrophages help hair growth after injury through CX3CR1 and TGF-β1.
36 citations,
September 2009 in “Journal of Cellular and Molecular Medicine” New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
33 citations,
October 2010 in “Journal of Dermatological Science” Hair follicle stem cells are a practical and ethical option for nerve repair in regenerative medicine.
31 citations,
April 2019 in “Cell reports” Patient-derived melanocytes can potentially treat vitiligo by restoring skin pigmentation.
31 citations,
January 2016 in “Drugs - Real World Outcomes” Some new oral anticoagulants may also cause hair loss and might not be better than traditional ones for preventing hair loss.
31 citations,
July 2015 in “Clinical, Cosmetic and Investigational Dermatology” Hair restoration surgery effectively treats hair loss with natural-looking results, using techniques like stem cells and platelet-rich plasma.
31 citations,
April 1999 in “Dermatologic Clinics” Nd:YAG laser can reduce hair with multiple treatments, but permanent removal isn't guaranteed.
28 citations,
October 2004 in “Differentiation” A gene deletion causes the "hairless" trait in Iffa Credo rats.
21 citations,
May 2016 in “The Cochrane library” Topical minoxidil helps treat female pattern hair loss, but more research needed for other treatments.
18 citations,
December 2018 in “Expert Opinion on Biological Therapy” Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.
14 citations,
May 2011 in “Facial Plastic Surgery Clinics of North America” Laser hair removal is effective for dark hair but needs improvement for nonpigmented or fine hairs.
11 citations,
February 2008 in “British journal of nursing” Idiopathic hirsutism causes excessive hair growth in women, can be treated with medication and hair removal, but cannot be fully reversed.
January 2018 in “Stem cell biology and regenerative medicine” ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.
December 2017 in “Springer eBooks” Transplant patients often get skin problems, with treatments varying by condition.
December 2015 in “Journal of Psoriasis and Psoriatic Arthritis” A patient experienced long-lasting hair loss after using acitretin for psoriasis.
479 citations,
January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
245 citations,
January 2018 in “Bone Research” TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.
207 citations,
January 2011 in “Dermatologic Therapy” Laser hair removal is the most requested cosmetic procedure and has become a scientifically-based treatment suitable for all skin types.
205 citations,
August 2007 in “Experimental Cell Research” Stem cell niches are crucial for regulating stem cell renewal and differentiation, and understanding them can help in developing regenerative therapies.
203 citations,
December 2004 in “Journal of The American Academy of Dermatology” Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.
139 citations,
August 2018 in “Development” The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.
120 citations,
February 2009 in “Apoptosis” Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.
115 citations,
November 2004 in “Brain Behavior and Immunity” Stress increases nerve fibers and immune cell activity in mouse skin, possibly worsening skin conditions.
86 citations,
May 2008 in “Cytokine & growth factor reviews” TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.