11 citations
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March 2014 in “Journal of The European Academy of Dermatology and Venereology” In this study, researchers found that androgen receptor gene polymorphism is associated with higher androgenetic alopecia grades and PSA levels in men with benign prostatic hyperplasia, but not with prostate cancer.
Androgenetic alopecia (AGA) is a common, hereditary hair loss condition that can be slowed but not permanently reversed with available therapies.
1 citations
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April 2017 in “Journal of Investigative Dermatology” This study found that the novel IPC analog SIG-1451 may inhibit inflammatory cytokine release in cell-based assays relevant to allergic dermatitis.
October 2023 in “University of Zadar Institutional Repository” This article reviews androgenetic alopecia, detailing its genetic and hormonal causes, clinical presentations, diagnosis, and treatment options, but it reports no new clinical findings.
4 citations
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September 2020 in “Frontiers in Microbiology” In this study, algal oligosaccharides effectively countered key factors in androgenetic alopecia pathogenesis, improving hair growth indicators in vitro and in mice.
August 2021 in “Journal of Investigative Dermatology” In this study, activated PRP injections appeared to promote hair growth in AGA-affected scalp skin transplanted onto mice, compared to non-activated PRP.
December 2023 in “Journal of Medicinal Chemistry” In this study, researchers identified compound 30a as a promising topical androgen receptor antagonist that promoted hair growth in mouse models of androgenetic alopecia without noticeable toxicity, suggesting its potential for treating this hair loss condition.
1 citations
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January 2023 in “The FASEB Journal” This study found that circAGK was highly expressed in AGA patients and promoted dermal papilla cell apoptosis, suggesting it as a potential target for treating androgen alopecia.
91 citations
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July 2004 in “Journal of Biological Chemistry” This study found that overexpression of the enzyme SSAT in a mouse model significantly reduced prostate tumor size and progression, suggesting it could be a promising strategy against prostate cancer.
28 citations
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March 2010 in “British Journal of Dermatology” This abstract contains only supplementary material information and reports no new research findings.
December 2022 in “Jurnal Kesehatan Jompa” This article reviews the causes and current treatment options for androgenetic alopecia, reporting no new clinical findings and highlighting the need for more therapeutic choices.
115 citations
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October 2009 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” In this study, researchers identified novel LMNA mutations in patients with atypical progeroid syndrome, revealing clinical features distinct from other similar disorders, but unrelated to mutant prelamin A accumulation.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review discusses recent advances in the understanding of androgenetic alopecia, focusing on genetic factors and new diagnostic and treatment approaches, but it does not provide new clinical results.
September 2019 in “Human Andrology” This study showed that men with androgenetic alopecia had higher serum levels of testosterone and DHT compared to controls, but no difference in PSA levels.
2 citations
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December 2018 in “International Journal of Dermatology” This study developed a new semiquantitative grading scale for frontal and vertex androgenetic alopecia, which was found to be more sensitive and objective than existing classifications.
29 citations
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November 2012 in “Journal of The European Academy of Dermatology and Venereology” This review discusses the development of an algorithmic guideline for treating androgenetic alopecia in Asian patients, using the BASP classification to address limitations of previous guidelines, and reports no clinical results.
9 citations
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September 2014 in “Cancer Epidemiology, Biomarkers & Prevention” This study found that men without prostate cancer carrying the A-allele of SNP rs1204038 had a 65% higher risk of PSA levels above 3 ng/mL compared to those with the G-allele, increasing referrals for further examination.
12 citations
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February 2021 in “Translational Psychiatry” This study identified two novel genetic variants associated with Alzheimer's disease in APOE ε4 non-carriers, revealing insights into the disease's underlying regulatory mechanisms.
80 citations
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January 1995 in “The American Journal of Medicine” Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.
June 2026 in “Health Science Reports” This review proposes a theoretical model for treating androgenetic alopecia using STEAP3 protein, based on recent findings about genetic mutations affecting molecular pathways, but emphasizes that this hypothesis needs validation through laboratory and clinical studies.
280 citations
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January 2004 in “The EMBO Journal” AGC2-1 protein is essential for root hair growth in Arabidopsis.
August 2019 in “Journal of The American Academy of Dermatology” No link found between hair loss severity and PSA levels in men.
22 citations
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August 2013 in “International journal of gynaecology and obstetrics” This study found that GAGS scores for acne were higher in younger women with PCOS and a lower BMI, but showed no association with levels of androgen hormones.
205 citations
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March 2012 in “Science Translational Medicine” PGD2 stops hair growth and is higher in bald men with AGA.
April 2024 in “European Journal of Dermatology” This study suggests that the PPP2R3C gene may confer susceptibility to psoriatic arthritis and psoriasis vulgaris in Chinese patients, with additional possible associations involving IL-23R, ERN1, IFIH1, and KIF3A genes.
February 2024 in “Benha Journal of Applied Sciences” This article reviews the current understanding, clinical features, diagnostic tests, and treatment options for androgenetic alopecia and reports no new clinical results.
1 citations
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September 2024 in “Benha Journal of Applied Sciences” This review provides an overview of androgenetic alopecia, detailing its causes, diagnostic methods, and current treatments, noting that combination therapies show promise but newer options like cell-based treatments require more research.
March 2026 in “Pediatric Dermatology” This study observed that GPT-4o, a generative AI model, showed high concordance with human providers in automating image-based SALT scores for assessing alopecia areata, suggesting its potential in assisting clinical evaluations without additional training.
June 2026 in “Value in Health”
February 2026 in “Archives of Dermatological Research” In this study, microneedle-assisted delivery of polyglutamate significantly improved hair parameters, scalp symptoms, and quality of life in androgenetic alopecia patients, with no serious adverse reactions reported.