In this pilot study, researchers found that fractional picosecond laser therapy may promote hair regrowth in men with mild-to-moderate androgenetic alopecia, with significant improvements in expert assessments and patient satisfaction observed over a four-month period, though further research is needed to confirm these findings.
2 citations
,
March 2016 in “The Journal of Dermatology” The researchers reported that the facial Psoriasis Log-based Area and Severity Index (fPLASI) more reliably and sensitively captured clinical improvement in facial psoriasis than the existing facial Psoriasis Area and Severity Index (fPASI).
January 2023 in “Dermatologic Therapy” In this randomized controlled trial, the nutritional supplement PPT5 α was associated with increased terminal hair percentages and improved self-assessed hair parameters in women with early-stage androgenetic alopecia.
This study found a significant association between androgenetic alopecia and metabolic syndrome, with AGA patients showing higher BMI, waist circumference, blood glucose, and cholesterol levels compared to controls.
30 citations
,
January 1997 in “ILAR Journal” This review details the development and genetic background of senescence-accelerated mouse strains, provides a comprehensive examination of their phenotypes, and highlights their importance for aging research, but reports no new experimental results.
This study found that platelet-rich plasma therapy may offer a simple and cost-effective treatment option for androgenetic alopecia in men, with around 70% of participants showing mild to excellent improvement.
9 citations
,
March 2015 in “Journal of Microbiology and Biotechnology” This study found that ultra-high molecular weight poly-γ-glutamic acid promoted hair growth in telogenic C57BL/6 mice by inhibiting 5-alpha reductase activity and inducing the anagen phase.
September 2018 in “Fertility and Sterility” In this study, researchers observed that overweight Taiwanese women with PCOS who carry the HSD3B1 1245C allele have a significantly higher risk of developing androgenic alopecia compared to those with the wild-type allele.
April 2011 in “Cancer Research” In this study, ginsenoside 20(S)-protopanaxadiol-aglycone (PPD) was shown to downregulate androgen receptor expression and inhibit tumor growth in prostate cancer cells.
40 citations
,
December 2004 in “Dermatology” This study suggests that an increase in kenogen phases, along with rising vellus hair cycles and fewer normal hair cycles, is associated with the progression of female androgenetic alopecia.
August 2024 in “Journal of Controlled Release” In a study using an AGA mouse model, researchers observed that a novel topical gel combining hybrid extracellular vesicles, gold nanoparticles, and finasteride accelerated hair regrowth and improved hair quality more effectively than conventional minoxidil treatment, presenting a promising option with fewer side effects.
February 2025 in “PLoS ONE” This study provides an overview of androgenetic alopecia in the USA, highlighting social determinants, differences in onset between genders, and how management varies by age and gender.
October 2020 in “Benha Journal of Applied Sciences” This study found that in patients with androgenetic alopecia, cardiac troponin I levels positively correlated with age and certain heart functions, indicating possible cardiac involvement in the disease's progression.
38 citations
,
July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
March 2017 in “European Urology Supplements” This study found that variations in (CAG)n and (GGN)n polymorphisms in the androgen receptor gene appear to influence symptom severity in men with post-finasteride syndrome.
May 2026 in “Premier journal of science.” This review examines androgenetic alopecia, detailing its causes and current treatments, but reports no new clinical results; the authors emphasize understanding its complexity for personalized therapy development.
22 citations
,
November 2024 in “Bioactive Materials” This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.
17 citations
,
August 2023 in “Frontiers in Pharmacology” This review highlights the potential of Asteraceae plants as antidiabetic agents and their beneficial effects on conditions such as cardiovascular disease and liver cirrhosis, suggesting their use as food and nutraceuticals could help manage diabetes.
15 citations
,
September 2018 in “Frontiers in Plant Science” This study identified that downregulation of the gene BcFLA1 decreases root hair length in Brassica carinata under phosphate-deficient conditions, highlighting its role in root hair elongation.
11 citations
,
December 2017 in “Orphanet Journal of Rare Diseases” This study found a previously unreported ST14 gene mutation in a patient with ichthyosis-hypotrichosis syndrome, highlighting novel skin and hair characteristics and emphasizing the critical role of the Asp482 amino acid in matriptase activation.
7 citations
,
January 2019 in “Journal of clinical medicine research” This study found that menopausal status and hormone therapy significantly affect the histology and gene expression of the introitus, with post-menopausal women showing notable tissue remodeling associated with vaginal atrophy.
January 2025 in “Human Reproduction Open” This study found that approximately 26% of women with Type 1 diabetes have undiagnosed androgen disorders, with polycystic ovary syndrome being the most common, particularly in those with premenarcheal onset of diabetes.
This article provides an overview of current treatments and alternative formulations for androgenic alopecia but reports no new clinical results.
24 citations
,
August 2005 in “Health and Quality of Life Outcomes” This study observed that women aged 63 with androgenetic alopecia had higher insulin resistance and more role limitations due to physical health compared to those with normal hair.
This review found that various treatments like finasteride, minoxidil, and platelet-rich plasma, combined with supplements, showed positive responses in combating androgenetic alopecia. The study specifically highlighted finasteride's effectiveness in increasing hair growth, with different dosages yielding notable improvements in both men and pre-menopausal women.
January 2015 in “Hair transplant forum international” This abstract introduces a historical perspective on Dorothy Osborn's research about the hereditary nature of common baldness but reports no new study results.
1 citations
,
February 2021 in “Benha Journal of Applied Sciences” This study found that ischemia-modified albumin (IMA) levels were significantly higher in patients with male pattern androgenetic alopecia compared to healthy controls, and these levels correlated with AGA duration and severity.
October 2024 in “Skin Appendage Disorders” This study evaluated the effects of autologous micrografts for androgenetic alopecia, reporting moderate improvements in hair loss reduction and hair density among most patients after treatment, with satisfactory results noted in patient satisfaction and treatment tolerability.
January 2015 in “Ankara Üniversitesi Tıp Fakültesi mecmuası” In this study, patients with advanced androgenetic alopecia stages had higher carotid intima media thickness and worse aortic elasticity, suggesting a potential link to subclinical atherosclerosis.
This study found that in Korean patients, cardiovascular disease-related risk was significantly associated with male sex, moderate to severe androgenetic alopecia, and particularly FV-type alopecia.