Androgenic Alopecia Associated with the HSD3B1 (1245A>C) in Overweight Women with Polycystic Ovarian Syndrome

The study investigated the association between the HSD3B1 (1245A>C) genotype and androgenic alopecia (AGA) in 472 Taiwanese women with polycystic ovarian syndrome (PCOS). It found that women with the HSD3B1 AC or CC genotype had a higher prevalence of AGA (23.2%) compared to those with the AA genotype (13.5%). This association was particularly strong in overweight women with PCOS (OR: 3.53, P=0.009). Women with PCOS and AGA also exhibited higher BMI, lower HDL-C, higher triglyceride levels, lower SHBG levels, and a higher incidence of hypertension. The study concluded that the HSD3B1 variant increases the risk of AGA and metabolic disturbances in overweight women with PCOS, despite the C allele's similar frequency in the general Taiwanese population.