1 citations
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October 2025 in “Experimental Dermatology” This study reports that mast cells are not only passive participants but also key regulators in skin aging, and their role as both protectors and accelerators of aging suggests they could be promising therapeutic targets for skin aging interventions.
January 2026 in “Biomolecules” This review suggests that the TSC22D family genes may influence metabolism and cancer, potentially serving as a therapeutic target for conditions like diabetes, obesity, and certain tumors, depending on the tumor environment.
May 2025 in “BMC Genomics” This study found that circ 0020938 suppresses hair follicle stem cell proliferation by interacting with the miR-142-5p/DSG4 axis, which aids in the hair follicle cycle's proper progression.
October 2024 in “Frontiers in Oncology” This review examines the potential of K18 as a diagnostic and prognostic marker in epithelial-derived tumors, highlighting its specific expression in tumor tissues and interaction with proteins involved in tumor progression, without reporting new clinical findings.
247 citations
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June 2021 in “Frontiers in Cell and Developmental Biology” This review discusses the role of lncRNA Xist in cell growth regulation and disease development, particularly cancer, and reports no new experimental results.
209 citations
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March 1998 in “Biochemical and biophysical research communications” This study identified a novel class of nonsteroidal ligands that can mimic the effects of dihydrotestosterone on androgen receptors, suggesting potential therapeutic applications in male fertility and hormone replacement therapy.
153 citations
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October 2012 in “Skin Pharmacology and Physiology” This review discusses the use of caffeine in cosmetics for its fat-reducing, antioxidant, and hair growth properties, but reports no new research findings.
108 citations
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January 2010 in “International Journal of Andrology” This study concluded that mixtures of weak endocrine disruptors, such as parabens and azole fungicides, can produce combination effects that should be considered in regulatory risk assessments to avoid underestimating potential risks.
96 citations
,
August 1995 in “Bone” This article reviews the essential role of vitamin D in bone health and its various clinical applications but reports no new clinical findings.
56 citations
,
July 2014 in “PLoS ONE” This study found that midazolam improved PTSD-associated behavioral deficits in rats through its action on the TSPO, CBR, and neurosteroidogenesis pathways.
52 citations
,
January 2003 in “Journal of Investigative Dermatology” This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.
49 citations
,
January 2017 in “Journal of Materials Chemistry B” This study developed a hydrogel from glycol chitosan and silica nanoparticles, which showed promise in wound healing by supporting microvessel and hair follicle growth in skin defects.
28 citations
,
November 2004 in “Endocrinology” This study by Gao et al. reports that two nonsteroidal selective androgen receptor modulators, S1 and S4, demonstrated tissue-selective actions in rats, suppressing prostate growth while maintaining muscle growth without altering hormone levels.
21 citations
,
December 2007 in “Journal of Investigative Dermatology” This study proposes the sebogenic hypothesis, suggesting that hair follicles evolved from primitive sebaceous glands to facilitate lipid transport and improve water retention in early land-dwelling animals.
17 citations
,
September 2022 in “Genes & Genomics” In this study, researchers identified specific long non-coding RNAs involved in feather development that do not follow traditional genetic inheritance patterns in chickens.
16 citations
,
September 2020 in “Animals” This study found that circRNA-1926 promotes hair follicle stem cell differentiation in cashmere goats by sponging miR-148a/b-3p to increase CDK19 expression.
10 citations
,
April 2008 This article explores the potential of chitin nanofibrils as a bioactive polymer for skin applications by examining their hydrophilic properties and effects on cell behavior, but presents no new experimental results.
10 citations
,
January 2000 in “PubMed” This study found that GnRH agonist treatment improved hirsutism scores more than finasteride after six months in women with idiopathic hirsutism, with both treatments causing no menstrual abnormalities or side-effects.
9 citations
,
June 2019 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)” A specific RNA increases hair stem cell growth and skin healing by affecting a protein through interaction with a microRNA.
8 citations
,
April 2011 in “Surgery today” This study found that sodium zinc dihydrolipoylhistidinate reduced chemotherapy-induced hair loss in rats, suggesting its potential as a treatment for this side effect.
7 citations
,
September 2004 in “International Journal of Cosmetic Science” This study demonstrated that visible light lightens blond hair more effectively than ultraviolet light, attacking melanin granules directly, whereas ultraviolet light primarily damages other hair tissues following washing.
6 citations
,
July 2023 in “Nature cell biology” In this study, re-activating SOX9 in adult epidermal stem cells led to a fate switch towards hair follicle stem cell identity, with altered chromatin dynamics and oncogenic activation, contributing insights into developmental processes and cancer pathways.
5 citations
,
January 1988 in “Analytical profiles of drug substances” Minoxidil helps lower blood pressure and can also promote hair growth.
4 citations
,
November 2024 in “International Journal of Molecular Sciences” This review explores whether SARS-CoV-2 could trigger or worsen α-synucleinopathies, like Parkinson's disease, by affecting α-synuclein misfolding and aggregation, potentially linking COVID-19 with the development of parkinsonism-like symptoms.
4 citations
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June 2024 in “The Kaohsiung Journal of Medical Sciences” This study found that in mouse embryonic fibroblast cells lacking autophagy function, overexpression of Atg5 increased cell proliferation, while restoring autophagy reversed this effect, highlighting Atg5's dual role in tumorigenesis depending on autophagy conditions.
2 citations
,
June 2023 in “PeerJ” This review discusses how chronic inflammation can lead to persistent stem cell activation and DNA damage, ultimately promoting cancer development and metastasis, but reports no new results.
1 citations
,
June 2023 in “Frontiers in Pharmacology” This study found that hydralazine and minoxidil, two direct vasodilators, may worsen abdominal aortic aneurysm progression by increasing aortic degeneration and inflammation.
1 citations
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April 2009 in “Expert Review of Dermatology” This study found that the once-daily gel combining calcipotriene and betamethasone dipropionate was more effective and faster in treating scalp psoriasis compared to individual treatments, with a similar safety profile.
This review highlights Malassezia's dual role as both protective and pathogenic within the hair follicle ecosystem, noting its involvement in skin disorders and potential cancer progression, and calls for further studies to develop targeted treatments for related conditions.
March 2026 in “South Asian Research Journal of Medical Sciences” In this case study, a 7-year-old boy with kerion celsi experienced persistent inflammation even after microbiological clearance; dermoscopic-guided removal of hair and keratin debris improved his condition, suggesting a novel inflammatory mechanism involving granulomatous response to keratinous debris in tinea capitis.