Minoxidil

January 1988 in “ Analytical profiles of drug substances ”

Dennis K.J. Gorecki

TLDR Minoxidil helps lower blood pressure and can also promote hair growth.

Minoxidil, initially developed as an antihypertensive agent, was effective in treating severe hypertension by acting as a direct-acting peripheral vasodilator, reducing both systolic and diastolic blood pressure. Despite significant side effects, it was particularly useful for hypertension not controlled by other medications. Additionally, minoxidil was found to be effective as a topical treatment for stimulating hair growth, specifically for alopecia androgentica.

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Research cited in this study

15 / 15 results

research Sulfation of Minoxidil by Human Platelet Sulfotransferase

39 citations , November 1987 in “Clinica Chimica Acta”

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

research Topical Minoxidil in the Treatment of Male Pattern Alopecia

7 citations , November 1987 in “Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy”

Minoxidil can help thicken hair in some people with male pattern baldness, especially if used early and continuously.

research Topical Minoxidil Dose-Response Effect in Alopecia Areata

54 citations , February 1986 in “Archives of Dermatology”

Higher minoxidil concentration (5%) works better for severe hair loss, with most patients seeing regrowth in 48-60 weeks.

research Alopecia Areata Treated With Topical Minoxidil

78 citations , April 1984 in “Archives of Dermatology”

Minoxidil can help regrow hair in alopecia areata patients.

research Electrochemical Studies on Minoxidil and Its Determination in Tablets by Differential-Pulse Polarography

25 citations , January 1983 in “Analyst”

Method measures minoxidil in tablets accurately and easily.

research Sulfation of Minoxidil by Liver Sulfotransferase

66 citations , September 1982 in “Biochemical Pharmacology”

Liver enzyme helps minoxidil work better for blood vessel relaxation.

research Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use

96 citations , October 1981 in “Drugs”

Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.

research Pharmacology and Pharmacokinetics of Minoxidil

57 citations , January 1980 in “Journal of Cardiovascular Pharmacology”

Minoxidil treats high blood pressure and side effects can be managed.

research Hypertrichosis Due to Minoxidil

73 citations , November 1979 in “British Journal of Dermatology”

Minoxidil can cause excessive hair growth.

research Long-Term Clinical Effects, Bioavailability, and Kinetics of Minoxidil in Relation to Renal Function

21 citations , October 1978 in “The Journal of Clinical Pharmacology”

research Minoxidil in Resistant Hypertension

102 citations , September 1977 in “The Lancet”

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

research Radioimmunoassay of Minoxidil in Human Serum

21 citations , September 1977 in “Journal of Pharmaceutical Sciences”

Minoxidil levels measured in human blood.

research Minoxidil-Induced Hypertrichosis: Treatment with Calcium Thioglycolate Depilatory Agent

46 citations , April 1977 in “Southern Medical Journal”

Minoxidil causes excessive hair growth, but depilatory agent removes it safely and effectively.

research Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

31 citations , August 1975 in “Journal of Pharmaceutical Sciences”

Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.

research Pharmacokinetic Studies of Minoxidil

90 citations , May 1972 in “Clinical Pharmacology & Therapeutics”

Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.

Related Research

6 / 6 results

Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

research Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

August 2023 in “Journal of Cosmetic Dermatology”

Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.

research Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes

8 citations , April 2019 in “Dermatologic Therapy”

Tretinoin boosts minoxidil's effect on hair loss by increasing enzyme activity.

research The Use of Minoxidil in the Treatment of Male and Female Androgenetic Alopecia: A Story of More Than 30 Years

5 citations , January 2018 in “Italian journal of dermatology and venereology”

Minoxidil effectively stimulates hair growth in androgenetic alopecia.

Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial

research Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial

1 citations , January 2010

Mesotherapy is more effective than topical spray for female hair loss treatment.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations , August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

research Androgenetic Alopecia: Treatment Results with Topical Minoxidil

39 citations , March 1987 in “Journal of The American Academy of Dermatology”

Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.