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    Glossary Acanthosis

    thickening of skin's outer layer, often with dark patches

    Acanthosis refers to the thickening of the skin's outer layer, often characterized by dark, velvety patches, typically found in body folds like the neck, armpits, and groin. This condition is commonly associated with insulin resistance, obesity, and certain hormonal disorders, and can be a marker for underlying health issues such as type 2 diabetes.

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    1. Acanthosis nigricans, insulin resistance and cutaneous virilism British Journal of Dermatology · 1988 · 43 citations
    2. Acanthosis nigricans and the metabolic syndrome Clinics in Dermatology · 2017 · 30 citations
    3. Insulin Resistance, Acanthosis Nigricans, and Polycystic Ovaries Associated with a Circulating Inhibitor of Postbinding Insulin Action The Journal of Clinical Endocrinology & Metabolism · 1985 · 24 citations
    4. Implications of a Clinically Ignored Site of Acanthosis Nigricans: The Knuckles Experimental and Clinical Endocrinology & Diabetes · 2014 · 9 citations
    5. Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome Case reports in endocrinology · 2015 · 7 citations
    6. Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance Dermato-endocrinology · 2018 · 6 citations
    7. A case of hyperpigmentation and acanthosis nigricans by testosterone injections Human & experimental toxicology · 2014 · 6 citations
    8. Global hotspots and trends in Acanthosis nigricans research: A bibliometric and visualized analysis Skin Research and Technology · 2024 · 3 citations
    9. Mania in Hyperandrogenism, Insulin Resistance, and Nigricans Acanthosis Syndrome ˜The œAmerican journal of psychiatry · 2002 · 3 citations
    10. A case of severe hyperandrogenism, acanthosis nigricans and overt diabetes: the use of non-invasive methods for diagnosis, pathogenesis and management Gynecological endocrinology · 1996 · 1 citations
    11. Ectopic acanthosis nigricans at a post-syndactyly surgical site: An unusual reactive epidermal phenomenon Journal of Cutaneous and Aesthetic Surgery · 2026
    12. Role of Metformin in Acanthosis Nigricans International Journal of Dermatology Venereology and Leprosy Sciences · 2026
    13. Hyperandrogenism insulin resistance-acanthosis nigricans syndrome in a female adolescent with migraine: A case report Indian Journal of Physiology and Pharmacology · 2025
    14. Acanthosis nigricans in adolescents with polycystic ovary syndrome International journal of reproduction, contraception, obstetrics and gynecology · 2022
    15. ACANTHOSIS NIGRICANS IN OBESE VERSUS NON-OBESE IN A TERTIARY CARE HOSPITAL ASSOCIATION WITH BMI AND CENTRAL OBESITY Zenodo (CERN European Organization for Nuclear Research) · 2021
    16. Acanthosis Nigricans during an HAIR-AN syndrome: "The Tree That Hides the Forest" Journal of clinical & experimental dermatology research · 2017
    17. Hyperandrogenism-insulin resistance-acanthosis nigricans syndrome with PCOS and Hashimoto's thyroiditis: case report International Journal of Research in Medical Sciences · 2015
    18. Acanthosis nigricans, insulin resistance and cutaneous virilism 1988
    19. The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome: therapeutic response Fertility and sterility · 1994 · 23 citations
    20. Review of facial acanthosis nigricans: Easy to diagnose and difficult to treat marker of hyperinsulinemia/metabolic syndrome Medical Journal Armed Forces India · 2024 · 2 citations
    21. Toxicity of Acanthospermum hispidum to mice Journal of comparative pathology · 1978 · 13 citations
    22. Dermoscopic features of infundibular keratinising acanthomas and follicular cysts: Description, assessment and histopathological correlation Veterinary Dermatology · 2025
    23. Obesity and the skin: Skin physiology and skin manifestations of obesity Journal of The American Academy of Dermatology · 2007 · 405 citations
    24. Phenotype and metabolic profile of South Asian women with polycystic ovary syndrome (PCOS): results of a large database from a specialist Endocrine Clinic Human Reproduction · 2010 · 111 citations
    25. Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation Molecular and cellular biology · 2002 · 108 citations
    26. Defining hirsutism in Chinese women: a cross-sectional study Fertility and Sterility · 2011 · 98 citations
    27. Diagnosis and management of the dermatologic manifestations of the polycystic ovary syndrome Dermatologic therapy · 2006 · 97 citations
    28. Diagnosis of hyperandrogenism: clinical criteria Best Practice & Research Clinical Endocrinology & Metabolism · 2006 · 85 citations
    29. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice EMBO molecular medicine · 2014 · 81 citations
    30. Dermatologic Manifestations of Polycystic Ovary Syndrome American Journal of Clinical Dermatology · 2007 · 76 citations