Acanthosis Nigricans During HAIR-AN Syndrome: The Tree That Hides the Forest

    January 2017 in “ Journal of clinical & experimental dermatology research ”
    Bérénice Dégboé, A Wanvoegbe, J Gninkoun, Attinsounon Ca, N Maffo, H. Adégbidi, F. Atadokpèdé, Patricia Yekpe, C. Koudoukpo, Fabrice Akpadjan, Nadège Agbéssi
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    TLDR The case shows skin changes can indicate deeper health issues like insulin resistance, which are challenging to manage.
    The document described a case of HAIR-AN syndrome in a 20-year-old female who exhibited acanthosis nigricans and symptoms of hyperandrogenism. Blood tests showed elevated levels of glucose, progesterone, testosterone, and cholesterol, and an ultrasound confirmed polycystic ovaries. HAIR-AN syndrome, which is rare and often found in young black African women, involves hyperandrogenism, insulin resistance, and acanthosis nigricans. The patient was treated with tretinoin, metformin, and dietary changes. The case highlighted the significance of skin manifestations as indicators of underlying insulin resistance syndromes and the associated risks of various comorbidities, underscoring the challenge in managing insulin resistance.
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