Acanthosis Nigricans During HAIR-AN Syndrome: The Tree That Hides the Forest

    January 2017 in “ Journal of clinical & experimental dermatology research ”
    Bérénice Dégboé, A Wanvoegbe, J Gninkoun, Attinsounon Ca, N Maffo, H. Adégbidi, F. Atadokpèdé, Patricia Yekpe, C. Koudoukpo, Fabrice Akpadjan, Nadège Agbéssi
    From the encyclopedia
    Tretinoin →

    the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

    Metformin →

    diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

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    Studysummary This report describes a case of HAIR-AN syndrome in a young woman, characterized by acanthosis nigricans, insulin resistance, and polycystic ovaries, highlighting its rarity and multisystem nature. Our plain-language summary of this paper — not a Tressless recommendation.
    The document described a case of HAIR-AN syndrome in a 20-year-old female who exhibited acanthosis nigricans and symptoms of hyperandrogenism. Blood tests showed elevated levels of glucose, progesterone, testosterone, and cholesterol, and an ultrasound confirmed polycystic ovaries. HAIR-AN syndrome, which is rare and often found in young black African women, involves hyperandrogenism, insulin resistance, and acanthosis nigricans. The patient was treated with tretinoin, metformin, and dietary changes. The case highlighted the significance of skin manifestations as indicators of underlying insulin resistance syndromes and the associated risks of various comorbidities, underscoring the challenge in managing insulin resistance.
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