Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome

The document reports on a 20-year-old female diagnosed with HAIR-AN syndrome, which is characterized by severe hyperandrogenism, insulin resistance, and acanthosis nigricans. She exhibited symptoms such as secondary amenorrhea, severe hirsutism, virilization, clitoridic hypertrophy, frontal alopecia, and acanthosis nigricans, with testosteronemia levels at 1.28 ng/mL. No tumors were found on imaging studies. The diagnosis was made clinically due to resource limitations, after excluding tumoral causes and identifying insulin resistance. Treatment included androcur, estradiol pills, and lifestyle modifications. The case emphasizes the importance of considering HAIR-AN syndrome in patients with severe hyperandrogenism and insulin resistance once tumor causes are ruled out.