Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome

    January 2015 in “ Case reports in endocrinology ”
    A.H. Dedjan, A. Chadli, S. El Aziz, A. Farouqi
    From the encyclopedia
    Cyproterone →

    a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

    Estradiol →

    an estrogen promoting hair regrowth more commonly used in women

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    Studysummary This case report indicates that HAIR-AN syndrome can lead to severe hyperandrogenism with virilisation signs in women after excluding tumoral causes and identifying signs of insulin resistance.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The document reports on a 20-year-old female diagnosed with HAIR-AN syndrome, which is characterized by severe hyperandrogenism, insulin resistance, and acanthosis nigricans. She exhibited symptoms such as secondary amenorrhea, severe hirsutism, virilization, clitoridic hypertrophy, frontal alopecia, and acanthosis nigricans, with testosteronemia levels at 1.28 ng/mL. No tumors were found on imaging studies. The diagnosis was made clinically due to resource limitations, after excluding tumoral causes and identifying insulin resistance. Treatment included androcur, estradiol pills, and lifestyle modifications. The case emphasizes the importance of considering HAIR-AN syndrome in patients with severe hyperandrogenism and insulin resistance once tumor causes are ruled out.
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