The Hyperandrogenic-Insulin-Resistant Acanthosis Nigricans Syndrome: Therapeutic Response

    March 1994 in “ Fertility and sterility
    Ricardo Azziz
    Image of study
    TLDR Most patients improved with oral contraceptives, but some needed additional treatment.
    The study investigated the therapeutic response of five women with hyperandrogenic-insulin-resistant acanthosis nigricans syndrome to oral contraceptives (OC) and spironolactone (SPA). After 6 months, four patients showed adequate suppression of free testosterone (T), increased sex hormone-binding globulin (SHBG) levels, and improved hair growth rate, with two also noting better hair texture. The fifth patient did not respond to OC therapy but showed significant improvement with GnRH-a suppression combined with hormonal replacement and SPA. The study concluded that while most patients respond well to OC treatment, GnRH-a suppression can be effective for those who do not. Hyperinsulinemia was found to enhance LH-stimulated androgen biosynthesis but could not sustain androgen production without sufficient gonadotropin stimulation.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 9 results

      community Proposed new pathogenesis model for androgenetic alopecia (AGA)

      in Research/Science  8 upvotes 1 year ago
      The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 11 months ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community Spironolactine Update: 2 months (34, Female)

      in Female  23 upvotes 8 years ago
      A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.

      community Reflex Hyperandrogenicty: How I recovered from it

      in Treatment 1 year ago
      The user experienced severe hair shedding from RU58841 and recovered by stopping its use and starting treatments including Minoxidil, Rosemary Verbenone, Stemoxydine, Aminexil, copper peptide serum, and specific shampoos. They also consistently used oral Finasteride and plan to try Minoxidil 10%.

    Similar Research

    5 / 1000+ results
      The Evaluation and Management of Hirsutism

      research The Evaluation and Management of Hirsutism

      11 citations, May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”
      Hirsutism in women often indicates a hormonal imbalance and can be managed with a combination of hormonal treatments and hair removal methods.
      Hirsutism

      research Hirsutism

      April 2008 in “Obstetrics, gynaecology and reproductive medicine”
      Hirsutism is often caused by high male hormone levels and can be treated with lifestyle changes and medications.
      The Evaluation and Management of Hirsutism

      research The Evaluation and Management of Hirsutism

      195 citations, May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”
      Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.