January 2023 in “Dermatologic Therapy” Androgenetic alopecia significantly affects mental health and quality of life, highlighting the need for psychiatric evaluations.
June 2019 in “Brain Imaging and Behavior” Hair loss can indicate brain aging and potential small vessel disease, but more research is needed to understand the clinical impact.
March 2019 in “Chinese Journal of Dermatology” Hair loss, known as androgenetic alopecia, is mainly caused by genetics, but also by hormone imbalances, shrinking hair follicles, inflammation, and environmental factors.
September 2016 in “Journal of Dermatological Science” The protein aPKCλ is crucial for keeping hair follicle stem cells inactive and for hair growth and regeneration.
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April 2001 in “Current Biology” c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.
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April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
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October 1999 in “EMBO journal” Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.
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June 2019 in “Cells” Different fibroblasts play key roles in skin healing and scarring.
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September 2001 in “Genes & development” CDP is crucial for lung and hair follicle cell development.
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August 2012 in “Seminars in cell & developmental biology” Hair growth and development are controlled by specific signaling pathways.
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May 2021 in “Frontiers in Medicine” Many patients experience long-lasting symptoms like fatigue and pain after COVID-19, regardless of initial disease severity.
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May 1988 in “Journal of The American Academy of Dermatology” "Male-pattern" hair loss is common in women, especially after menopause, and doesn't always mean there's a problem with hormone balance.
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January 2008 in “PloS one” Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.
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December 2016 in “Pharmaceuticals” TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
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April 1995 in “Journal of Cutaneous Pathology” The document describes how to tell different types of non-scarring hair loss apart by looking at hair and scalp tissue under a microscope.
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January 2021 in “medRxiv (Cold Spring Harbor Laboratory)” COVID-19 can cause over 50 long-term symptoms, with fatigue and headache being the most common.
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June 1997 in “PubMed” EGFR is essential for normal hair development and follicle differentiation.
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October 2017 in “Stem cells” Wnt signaling is crucial for skin development and hair growth.
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June 2006 in “British journal of sports medicine” The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.
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September 2004 in “Clinics in dermatology” Blocked hair follicles cause acne, and studying tiny early acne spots helps understand its severity.
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February 2019 in “The New England Journal of Medicine” Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.
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August 1975 in “Journal of Cutaneous Pathology” Male pattern baldness involves smaller hair follicles, larger oil glands, and other tissue changes, but not major blood supply issues.
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May 2005 in “The Journal of Clinical Endocrinology & Metabolism” A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.
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February 1989 in “Journal of The American Academy of Dermatology” Children with loose anagen hair have easily pluckable hair due to root sheath problems, and it might improve without treatment.
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February 2011 in “Canadian Medical Association Journal” Acne treatment varies, with topical and systemic therapies effective, and more research needed on treatment order and long-term effects.
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August 1999 in “Developmental biology” The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.
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August 2018 in “Frontiers in Endocrinology” Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.
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June 1997 in “Baillière's clinical obstetrics and gynaecology” PCOS is often caused by hormonal imbalances that can lead to various health issues and may indicate a risk for future metabolic and cardiovascular problems.
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April 2009 in “Differentiation” SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.
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June 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” Frontal fibrosing alopecia mainly affects postmenopausal women and may be linked to thyroid hormones.