December 2025 in “Nature Communications” This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.
22 citations
,
January 2001 in “Chemical & Pharmaceutical Bulletin” This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.
45 citations
,
January 2008 in “Drugs” This study found that dutasteride effectively improved urinary symptoms, reduced acute urinary retention risk, and decreased prostate volume in men with moderate to severe BPH over two years.
20 citations
,
June 2020 in “Stem Cell Research & Therapy” This study found that treating acute and chronic canine skin wounds with adipose-derived mesenchymal stem cells significantly improved healing and reduced inflammation, suggesting potential benefits for human wound care.
15 citations
,
November 2002 in “Cardiology in Review” This review discusses various adverse skin reactions linked to cardiovascular medications and reports no new clinical results, highlighting the need for vigilance when prescribing these drugs.
7 citations
,
October 2024 in “AAPS PharmSciTech” This study developed a caffeine-loaded solid lipid nanoparticle gel, observing significant reduction in subcutaneous fat tissue thickness in histological tests compared to an untreated group, suggesting it could effectively treat cellulite as a promising nanocosmeceutical gel.
7 citations
,
September 2024 in “Applied Microbiology and Biotechnology” In this study, researchers observed that Malassezia species show different lipid metabolism and growth patterns depending on pH, with slightly acidic conditions promoting beneficial lipid bio-conversion for skin health, while neutral pH resulted in lower growth and lipid content, potentially negatively impacting the skin.
2 citations
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January 2018 in “International Journal of Biochemistry & Physiology” This study identified two new Wnt genes, EsWnt1 and EsWnt4, in red starfish, with their expression patterns suggesting a role in wound healing and regeneration.
1 citations
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June 2024 in “PLoS ONE” This study found that implanting hair-follicle-associated pluripotent stem cell sheets facilitated wound healing and early macrophage activity while reducing inflammation in a diabetic mouse model, suggesting clinical potential for difficult-to-heal diabetic ulcers.
January 2022 in “Kafkas Universitesi Veteriner Fakultesi Dergisi” In this study, differences in protein expression related to twin lambing were identified in Tibetan sheep, providing insights into the reproductive performance and fertility improvement strategy for sheep in the Qinghai-Tibet Plateau.
December 2023 in “Sains Malaysiana” In this study, researchers used in silico mutagenesis to identify key calcium-binding sites influencing the stability of Rand protease from Bacillus subtilis, potentially enhancing its application in industries like leather dehairing by improving stability and eliminating the need for additional metal ions during the process.
January 2026 in “Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)” This study involved analyzing hair-removal advertisements and conducting focus group interviews with 28 female university students in Budapest to explore societal attitudes toward female body hair removal, aiming to understand the reasons behind its strong norm compliance.
January 2025 in “Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)” In this study, baricitinib was found to be effective and safe for treating severe alopecia areata, with significant hair regrowth observed in many patients by the third month of therapy and continued improvement by the twelfth month, despite mostly mild adverse events.
6 citations
,
September 2024 in “Metabolism and Target Organ Damage” This review discusses the role of skin enzymes in drug metabolism and emphasizes the need for models assessing enzyme activity to evaluate the safety and bioequivalence of topical generic drugs, highlighting efforts to standardize testing protocols for transdermal products.
238 citations
,
March 2013 in “Development” This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.
13 citations
,
December 2024 in “Cellular and Molecular Life Sciences” This study reviews recent advancements in understanding caspases, highlighting their roles beyond apoptosis in cancer, inflammation, and neurological disorders, and discusses the potential and challenges of targeting caspases for therapeutic purposes.
25 citations
,
August 2017 in “Lasers in Medical Science” This literature review reported that fractional lasers, like the 1550-nm nonablative erbium-glass laser, may enhance hair regrowth by stimulating a wound healing process, but more randomized controlled trials are needed to confirm their effectiveness and optimize treatment parameters.
December 2017 in “Springer eBooks” Treat pediatric skin issues with accurate diagnosis, multidisciplinary team, and various treatment options.
5 citations
,
January 2019 in “Elsevier eBooks” This chapter reviews skin components, wound healing mechanisms, and the potential of biomaterials to enhance skin repair and regeneration, without offering new experimental results.
March 2024 in “Cell communication and signaling” This study found that sleep deprivation in mice can trigger prostatitis by activating the cGAS-STING pathway due to reduced levels of dihydrotestosterone and melatonin, resulting in a pro-inflammatory environment, while recovery sleep can mitigate these effects.
May 2022 in “Current Enzyme Inhibition” This study found that the synthesized compound 7b exhibited higher 5α-reductase inhibitory activity, increased solubility, and dissolution compared to finasteride, suggesting its potential as a lead compound for benign prostatic hyperplasia treatment.
22 citations
,
August 2015 in “PloS one” This study found that the binding and release of BMP-2 from kerateine biomaterials are significantly influenced by pH and salt concentration, highlighting the potential for developing improved bone repair systems.
March 2026 in “Molecules” This review reports that Dang Gui (Radix Angelica sinensis) possesses bidirectional immunoregulatory effects, enhancing immune cell proliferation and function, and may benefit immune-related diseases such as cancer and anemia. It also evaluates regulatory and safety aspects, aiming to guide future research and clinical use.
11 citations
,
July 2024 in “Biomimetics” This manuscript explores the development and future potential of injectable biomimetic gels in biomedical applications, highlighting their promise in wound healing and tissue regeneration, while also acknowledging challenges like mechanical durability and scalable production still persist.
23 citations
,
January 2014 in “Molecular Therapy” This study found that topically delivering KGF-1 DNA plasmid increased epithelial thickness and skin strength, suggesting potential benefits for strengthening compromised skin.
November 2023 in “Materials Today Bio” This article discusses photobiomodulation as a potential adjunct to hair follicle organoid culture for androgenic alopecia, reporting no new results and suggesting further study is needed.
22 citations
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March 2021 in “Materials Today Bio” This review discusses recent advances in developmental tissue engineering for regenerating ectodermal appendages like teeth and glands, emphasizing biomaterial selection and cell culture strategies, but reports no new experimental results.
October 2025 in “Materials Today Bio” In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.
August 2025 in “Materials Today Bio” This study reports that novel nanofibrous dressings combining polylysine and tannic acid significantly reduce bacterial burden, support wound healing, and exhibit strong anti-inflammatory effects in infected full-thickness wounds, promoting near-complete closure and skin regeneration within two weeks.
July 2025 in “Materials Today Bio” This study suggests that curcumin-loaded nanoparticles, which activate autophagy and reduce oxidative stress, showed promise in promoting hair growth in an androgenetic alopecia mouse model.