TLDR Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.
The study synthesized and characterized a series of 5α, 6β-Dichloro-17-Oxoandrostan-3β-yl esters (7a-7f) to evaluate their 5α-reductase inhibitory activity. The compounds demonstrated increased anti-androgenic activity compared to finasteride, with compound 7b showing the highest inhibitory activity and improved solubility and dissolution properties. These findings suggest that the presence of an electronegative group at position 3 enhances the activity, making compound 7b a promising candidate for further development and formulation against benign prostatic hyperplasia and prostate cancer.
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