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Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

Sebocytes play a key role in controlling androgen levels in human skin.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Dutasteride works better than finasteride for hair loss, with both being safe to use.

Testosterone helps human pancreatic cells increase insulin release.

Compounds from the plant Mammea siamensis may help treat hair loss.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.

Dutasteride injections can help hair growth in androgenic alopecia but need more research for long-term use.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.