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Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

Avicennia marina extract and avicequinone C can potentially promote hair growth and treat hair loss by interfering with hair loss mechanisms and boosting growth factors.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

A new plant extract from Avicennia marina could potentially be used to treat common hair loss.

Ginseng, especially red ginseng, may help regrow hair and block a hair loss-related enzyme.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Finasteride and spironolactone both reduce hirsutism, but finasteride lowers androgen levels more.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

Finasteride may increase erectile dysfunction risk in patients with benign prostatic hyperplasia.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Low-dose finasteride reduces excessive hair growth in teenage girls safely and affordably.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Finasteride may affect PNMT, causing side effects.

5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Hormonal therapy is a treatment option for acne, the only medical treatment for hirsutism, and the most promising for androgenetic alopecia.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

Testosterone helps human pancreatic cells increase insulin release.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.