22 citations,
March 2000 in “Clinics in Dermatology” Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.
August 2021 in “Skin appendage disorders” Two people lost hair unexpectedly after getting a common hair loss treatment with a drug called Dutasteride.
10 citations,
March 2016 in “Journal of The American Academy of Dermatology” Finasteride's effectiveness for frontal fibrosing alopecia is uncertain.
3 citations,
April 2010 in “Endocrinology” The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.
January 2016 in “프로그램북(구 초록집)” Hormones and neuropeptides affect hair growth, with androgens having opposite effects on beard and scalp hair.
10 citations,
December 1995 in “Journal of women's health” Finasteride reduces hair growth in women with hirsutism and works better with electrolysis.
Nepenthes kampotiana extract can potentially prevent hair loss and could be an effective treatment for common baldness.
November 2022 in “Journal of Investigative Dermatology” The lotion with specific plant extracts effectively increased hair growth and improved hair cycle in subjects after 3 months.
77 citations,
March 2001 in “Clinics in Dermatology” Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.
August 2016 in “Journal of Investigative Dermatology” DHT reduces a cell's ability to promote hair growth, while 3D culture without DHT improves it.
5 citations,
July 2022 in “Orphanet journal of rare diseases” RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.
237 citations,
December 2001 in “Urology” Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.
29 citations,
January 1996 in “Journal of Pharmaceutical Sciences” Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.
May 2018 in “Más dermatología” The higher dose supplement was more effective in treating female hair loss.
September 2016 in “Journal of Dermatological Science” Wnt-10b is important for keeping mouse skin cells healthy for hair growth.
17 citations,
May 1998 in “Steroids” Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.
February 2015 in “Current Opinion in Endocrinology, Diabetes and Obesity”
June 2023 in “Oriental Journal of Chemistry/Oriental journal of chemistry” New compounds may help treat prostate cancer by reducing cell growth.
10 citations,
June 2001 in “PubMed” Finasteride is effective in growing hair and stopping hair loss in men with mild to moderate alopecia.
2 citations,
January 2004 in “Enshou saisei” Male pattern baldness is caused by certain cells in hair follicles and could potentially be treated by targeting a specific growth factor, TGF-β1.
72 citations,
April 2008 in “The Journal of urology/The journal of urology” Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.
January 2022 in “Journal of St. Marianna University” Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
8 citations,
June 2020 in “The Journal of Clinical Endocrinology and Metabolism” Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.
June 2018 in “The Journal of Sexual Medicine” Men with lower education levels are more likely to have erectile dysfunction if they have coronary artery disease.
56 citations,
April 1998 in “Steroids” Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.
416 citations,
September 1997 in “Journal of Investigative Dermatology” People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
101 citations,
April 1994 in “Baillière's clinical endocrinology and metabolism” 5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.
November 2012 in “Endocrine Practice” Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
44 citations,
July 2012 in “Endocrine Practice” We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
May 2024 in “Archives of dermatological research” Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.