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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.

Schisandra nigra extract may help hair grow by stimulating cells and preventing hair follicle damage.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Late pregnancy helps repair brain damage in rats due to the GABAergic system.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

PCOS is a genetic disorder affecting women's reproductive health, with treatments focused on symptoms like insulin resistance and fertility.

Testosterone increases acidification in the vas deferens by up-regulating V-ATPase.

Hair growth is influenced by hormones and goes through different phases; androgens can both promote and inhibit hair growth depending on the body area.

Vitamin D receptor is crucial for skin wound healing.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

New oral testosterone formulations show potential for safer, effective hormone replacement in men with low testosterone.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Hair loss in balding individuals is linked to changes in specific hair growth-related genes.

New research on prostamide F2α has led to treatments for glaucoma and eyelash growth and may have more medical uses.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

The review concludes that more research is needed to better improve the health outcomes for people with Polycystic Ovarian Syndrome.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Natural products may help treat hair loss by promoting hair growth with fewer side effects.