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We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Gene differences may affect baldness treatment response in Korean men.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Finasteride effectively treats male hair loss, improving growth and density.

Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

Testosterone helps human pancreatic cells increase insulin release.

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

Minoxidil may help treat hair loss by reducing the activity of a specific enzyme linked to baldness.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

Plant extracts like Avicennia marina, Boehmeria nipononivea, and Camellia sinensis could potentially treat hair loss with fewer side effects than synthetic drugs.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Medications for enlarged prostate can cause sexual side effects like reduced libido, erectile dysfunction, and ejaculatory problems.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Men using hair loss drugs like finasteride may experience sexual side effects like erectile dysfunction, but it's unclear who will be affected and when. Treating depression and sexual symptoms is suggested, as these men often have higher rates of both. More research is needed to understand why these side effects occur.

5-alpha reductase inhibitors can cause sexual, neurologic, endocrine, and cardiovascular side effects, but these are rare and usually stop after ending treatment.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Dutasteride works better than finasteride for hair loss, with both being safe to use.

Four-amino acid part makes enzyme sensitive to finasteride.