August 2023 in “Research Square (Research Square)” This study found that two microRNAs, oar-miR-23b and oar-miR-133, inhibit the development of hair follicles in superfine wool sheep by targeting genes involved in key signaling pathways, suggesting their potential use as molecular markers for breeding fine wool sheep.
July 2023 in “Research Square (Research Square)” This study offers evidence suggesting a probable causal role of certain gut microbiota in the development of alopecia areata.
July 2023 in “Research Square (Research Square)” This study developed finite element models to examine skin's biomechanical properties, finding that structural heterogeneities like Rete ridges and hair follicles create distinct stress and strain patterns that may influence mechanosensation and skin integrity.
July 2023 in “Research Square (Research Square)” In this study, the application of topical cetirizine 1% once daily for four months in Egyptian male patients with androgenetic alopecia led to a significant increase in terminal hairs and improved hair diversity, with promising safety and efficacy outcomes.
July 2023 in “Research Square (Research Square)” In this case report, Triamcinolone Acetonide injections effectively improved mouth opening in patients with Oral Submucous Fibrosis, but both developed symptoms of Cushing's Syndrome, prompting the need for careful monitoring due to potential adverse effects when using this treatment.
July 2023 in “Research Square (Research Square)” In this study conducted on rabbits, conventional blood treated with 120% sodium citrate was observed to achieve the highest platelet recovery and enrichment coefficient, while altering sodium citrate concentrate affected levels of growth factors PDGF and TGF-β1 after plasma activation.
July 2023 in “Research Square (Research Square)” In an in-vitro study, researchers found that a specific concentration of Aloe Vera combined with injectable platelet-rich fibrin (i-PRF) significantly increased hair follicle stem cell proliferation compared to Aloe Vera or i-PRF alone, indicating potential benefits for alopecia treatment.
June 2023 in “Research Square (Research Square)” This study demonstrated that dietary cupric citrate improved growth performance and nutrient utilization in broilers, while also altering their intestinal microbiota and increasing the pH in the duodenum and jejunum.
June 2023 in “Research Square (Research Square)” This study identified shared gene expression changes and immune cell infiltration patterns that may contribute to hair loss in alopecia areata and cutaneous lupus erythematosus, but also highlighted factors that might preserve hair in psoriasis patients.
June 2023 in “Research Square (Research Square)” In this study, researchers used spatial transcriptome profiling to identify immune disturbances in the peri-infundibular region of androgenetic alopecia patients’ hair follicles, finding increased CD4+ T cells with a bias toward Th2 immune responses compared to controls.
June 2023 in “Research Square (Research Square)” In this study, utilizing a mixture of crushed sky fruit seeds and sodium salt for goat skin preservation led to a significant reduction in environmental impact, decreasing total dissolved solids by 59% and chloride content by 44%, while maintaining the physical quality of processed leather.
June 2023 in “Research Square (Research Square)” This study found that among male Han Chinese, a higher polygenic risk score was linked to increased risk and poorer treatment outcomes for benign prostatic hyperplasia.
May 2023 in “Research Square (Research Square)” This study observed that the Hedgehog-GLI1 signaling pathway is upregulated in keloid patient–derived stem cells, and inhibiting this pathway reduced keloid characteristics in both mice and ex vivo tissue cultures, suggesting potential therapeutic targets for keloid treatment.
May 2023 in “Research Square (Research Square)” This study found that botulinum toxin type A may reduce apoptosis in dermal papillary cells induced by dihydrotestosterone through the circ_0135062/miR-506-3p/Bax axis.
May 2023 in “Research Square (Research Square)” This study found that the natural product Shi-Bi-Man significantly promoted hair regeneration in cynomolgus monkeys, increasing hair follicle number and activation by boosting specific protein markers and interactions in Laminin-related pathways.
May 2023 in “Research Square (Research Square)” In this study, researchers observed that treatment with Agaricus subrufescens ethanolic extract improved blood glucose, testosterone levels, and menstrual irregularity in rat models of letrozole-induced Polycystic Ovarian Syndrome, also noting a decrease in elevated liver and ovary weights, suggesting protective effects on renal function.
April 2023 in “Research Square (Research Square)” This study found that lower GPX4 mRNA levels in polymorphonuclear neutrophils of systemic lupus erythematosus patients were negatively associated with disease activity and serological markers, suggesting a diagnostic value for GPX4 mRNA.
April 2023 in “Research Square (Research Square)” In this study, gene therapy using a VDR-expressing adenoviral vector significantly improved hair growth and reduced cyst formation in Vdr -KO rats with alopecia linked to type II rickets, whereas control treatments did not show these effects.
April 2023 in “Research Square (Research Square)” The researchers reported that combining stromal vascular fraction (SVF) with fractional CO2 laser treatment significantly improved burn scar outcomes and patient satisfaction compared to using the laser alone.
April 2023 in “Research Square (Research Square)” This study found that FUE hair transplantation for male androgenetic alopecia results in a high hair follicle survival rate and patient satisfaction, with a low complication rate.
April 2023 in “Research Square (Research Square)” This case study of a young Palestinian woman illustrates the diagnostic and treatment challenges of ovarian steroid cell tumors, highlighting the importance of detailed examination when hormonal therapy fails.
April 2023 in “Research Square (Research Square)” This case report highlights a Palestinian woman with a rare ovarian steroid cell tumor, underscoring the diagnostic challenges and potential for disease progression despite treatment attempts with various chemotherapy regimens.
This study found that Wnt7a protein expression increased after corneal epithelial injury and promoted human corneal epithelium cell proliferation by upregulating fibronectin and enhancing cell adhesion.
April 2023 in “Research Square (Research Square)” This study found that melatonin-mediated lncRNA018392 accelerated cell proliferation and inhibited apoptosis in cashmere goat skin fibroblasts by upregulating the expression of the nearby gene CSF1R.
February 2023 in “Research Square (Research Square)” This case report describes a 16-month-old girl with atypical acrodermatitis enteropathica who showed marked improvement after zinc supplementation despite normal serum zinc levels.
February 2023 in “Research Square (Research Square)” This study found that testosterone contributed to increased arterial stiffness and cardiovascular damage in female mice, linked with decreased estrogen receptor expression, and suggests implications for women with polycystic ovarian syndrome or those taking testosterone.
February 2023 in “Research Square (Research Square)” This study found that ApoEVs derived from mesenchymal stem cells improved cutaneous wound healing in diabetic mice by inhibiting macrophage pyroptosis and reducing oxidative stress levels.
February 2023 in “Research Square (Research Square)” This study reports that a new mouse model with a CARD14 mutation successfully mimics key human PRP symptoms, and anti-IL-17A antibody significantly reduces these symptoms.
January 2023 in “Research Square (Research Square)” This study suggests that measuring cortisol levels in hair may serve as a useful biomarker for assessing mood in individuals with bipolar disorder over recent months.
January 2023 in “Research Square (Research Square)” This study found that glycated proteins in untreated scalp hair may serve as a non-invasive marker for blood glucose control, but its applicability is limited by factors like cosmetic treatments and sample collection challenges.