Investigation of the Effect of Anticoagulants on Platelet Recovery, Enrichment Factor, PDGF, TGF-β1, and Optimal Dose in the Preparation of Platelet-Rich Plasma

July 2023 in “ Research Square (Research Square) ”

Chao Chen, Jun Lei, Xinming Yi, ye Hua, Jun Yang

platelet-rich plasma sodium citrate platelet recovery platelet-derived growth factor transforming growth factor beta 1 PRP PDGF TGF-β1

TLDR Using 120% sodium citrate in blood gives the best platelet recovery and enrichment.

The study investigated the effect of different doses of sodium citrate as an anticoagulant on platelet recovery and enrichment in platelet-rich plasma using 9 New Zealand rabbits. The results showed that using 120% sodium citrate in conventional blood resulted in the highest platelet recovery rate and enrichment coefficient, indicating effective separation and good biological function. The study also observed changes in platelet-derived growth factor (PDGF) and transforming growth factor (TGF-β1) levels, with significant increases before plasma activation and varied effects after activation depending on the concentration of blood and sodium citrate used.

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Investigation of the Effect of Anticoagulants on Platelet Recovery, Enrichment Factor, PDGF, TGF-β1, and Optimal Dose in the Preparation of Platelet-Rich Plasma

Research cited in this study

research Platelet Rich Plasma and Its Use in Hair Regrowth: A Review

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research Investigating the Safety and Efficacy of Platelet-Rich Plasma Treatment for Female Androgenetic Alopecia: Review of the Literature

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