Agaricus Subrufescens Ameliorates Ovarian Dysfunction in Rats with Letrozole Induced Polycystic Ovarian Syndrome

The study examined the effects of Agaricus subrufescens extract on 30 female Wistar rats with letrozole-induced Polycystic Ovarian Syndrome (PCOS). The rats were divided into five groups of six, with one group serving as a control. The test group received Agaricus subrufescens extract (200 mg/kg, 400 mg/kg) from the 22nd to the 36th day. The results showed that the extract reduced blood glucose, testosterone levels, anovulation, and menstrual irregularity. It also corrected SGOT and SGPT levels, protected renal function by lowering serum urea and creatinine, and decreased endocrine organ weight. Histopathology of the PCOS control group showed more cysts and theca lutein cells, which were less in the treatment groups.