Investigation on Antimicrobial, Antioxidant, and Anti-Cancerous Activity of Agaricus Bisporus Derived Beta-Glucan Against Cervical Cancer Cell Line

    September 2022 in “ Cellular and molecular biology ”
    Ankita Bhosale, Rashmi Trivedi, Tarun Kumar Upadhyay, Dhruvi Gurjar, Faranak Aghaz, Fahad Shahbaz Khan, P. N. Pandey, Md. Zeyaullah, Md Shane Alam, Mohammad A A Al-Najjar, Samra Siddiqui
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    TLDR Agaricus bisporus derived β-Glucan could be an effective cervical cancer treatment with antimicrobial and antioxidant properties.
    The study investigated the potential of Agaricus bisporus derived β-Glucan particles (ADGPs) as a treatment for cervical cancer, as well as their antimicrobial and antioxidant properties. The β-Glucan was confirmed to have 1,3 glycosidic linkages and showed effective antimicrobial activity against various tested strains. Antioxidant activity was verified using the DPPH assay. The anticancer efficacy was tested on HeLa cervical cancer cells, with an IC50 value of 54μg/ml indicating the concentration needed to inhibit cell viability by 50%. The β-Glucan induced apoptosis in cancer cells through the generation of reactive oxygen species (ROS) and disruption of Mitochondrial Membrane Potential (MMP), as evidenced by Propidium Iodide (PI) and JC-1 staining, respectively. The results suggest that ADGPs could be an effective therapy for cervical cancer, with additional antimicrobial and antioxidant benefits.
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