Efficacy of Fractional CO2 Laser in Combination With Stromal Vascular Fraction Compared With Fractional CO2 Laser Alone in the Treatment of Burn Scars: A Randomized Controlled Clinical Trial

    April 2023 in “ Research Square (Research Square) ”
    Masoumeh Roohaninasab, Fariba Khodadad, Afsaneh Sadeghzadeh‐Bazargan, Najmolsadat Atefi, Samad Zare, Alireza Jafarzadeh, Seyyedeh Tahereh Rahimi, Maryam Nouri, Mohammad Ali Nilforoushzadeh, Elham Behrangi, Azadeh Goodarzi
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    TLDR Combining stromal vascular fraction (SVF) injections with fractional CO2 laser treatment is more effective for treating burn scars than using the laser alone.
    The study compared the effectiveness of fractional CO2 laser treatment alone and in combination with stromal vascular fraction (SVF) injections in treating burn scars. The double-blind clinical trial involved 10 patients who received three treatments of fractional CO2 laser on their burn scars, with one of two areas randomly selected for SVF injection. Two months post-treatment, the scars were evaluated using the Vancouver Scar Scale (VSS), biometric criteria, and satisfaction ratings from both physicians and patients. The results showed significant improvement in both treatment groups, but the group treated with the combination of SVF and fractional CO2 laser showed better results in VSS criteria, melanin index of Mexameter, and higher satisfaction ratings from both physicians and patients. Therefore, the study concluded that SVF injection combined with fractional CO2 laser is an effective treatment for burn scars.
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