Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review summarizes research on androgens' roles in female reproductive function, noting their impact on IVF outcomes and the development of PCOS, and highlights the need for mechanism-based therapies.

In this study, manipulation of the enzyme 5α-reductase type 2 in human hepatocytes altered lipogenesis, suggesting clinical implications for patients using 5α-reductase inhibitors by affecting glucocorticoid action on hepatic lipid metabolism.

This systematic review and meta-analysis reported potential risk variants for acne in genes related to inflammation and sebaceous gland function, including TNF, CYP17A1, and FST, across diverse populations.

This review discusses using human follicular fluid in metabolomic analysis as a diagnostic tool and predictor of success in assisted reproductive technology for PCOS patients, reporting no new results.

mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.

This study observed that maize plants enhance phosphorus acquisition by promoting both root hair growth and lateral root development in response to localized nutrient patches, highlighting a complementary root trait trade-off.

In this study, researchers used transcriptomics and modeling to uncover previously unknown cell populations and marker genes in developing hair follicles, providing insights into early cell fate establishment and offering tools for further research on skin appendages.

This review discusses three classes of thiazole-bearing compounds in drug development and presents preclinical findings but reports no new experimental results, highlighting the need for further drug discovery.

This study identified a shared gene signature in scarring alopecia subtypes, with increased mast cell presence, suggesting similar treatment approaches may be effective across these hair loss disorders.

This review discusses psychological impacts associated with facial acne, noting that high levels of anxiety and depression among these patients are not linked to oxidative stress, and reports no new clinical results.

This study found that a 3D co-culture of endothelial colony-forming cells and adipose-derived stem cells restored stem cell properties and improved healing in a mouse model of chronic injury.

This study found that the retinol dehydrogenases SDR16C5 and SDR16C6 in mice play a crucial role in skin retinol dehydrogenase activity, affecting hair growth and gland functions without impacting survival.

In this study, A. capillus-veneris solution demonstrated potential to reduce hair loss and improve hair characteristics in a testosterone-induced alopecia mouse model.

This study found distinct expression patterns of various transcription types during hair follicle morphogenesis, providing a foundation for understanding hair development mechanisms and aiding selective breeding for desirable wool traits in a specific breed.

This study found that early passage dermal papilla cell-derived extracellular vesicles, combined with specialized medium, helped adipose-derived stem cells develop dermal papilla-like properties.

In this study, SNPs in genes affecting skin pigmentation were linked to each skin type's unique response to environmental stress, suggesting potential for personalized skin care products.

This study found that bolandiol increased lean body mass and bone mineral density in castrate adult male rats, exhibiting tissue selectivity and acting through multiple receptor pathways with less potency compared to other androgens.

This review explores epidermolysis bullosa simplex subtypes caused by mutations in KRT5 or KRT14 and summarizes gene expression patterns and molecular mechanisms, without presenting new experimental results.

This review discusses the roles of steroid hormone receptors in lung function related to COVID-19 and outlines ongoing clinical trials of steroid receptor ligands, but reports no new results.

Finasteride reduces opioid use and withdrawal symptoms in animals.

This study suggests that LONRF1 may play a vital role in linking oxidative damage responses and tissue remodeling during wound healing, with distinct mechanisms in senescent and non-senescent cells.

This study suggests that guava leaf extract may inhibit hair loss by downregulating genes involved in androgen synthesis, potentially offering a natural alternative for treating androgenetic alopecia.

This study found that tomato plants inoculated with Enterobacter sp. SA187 grew better under salinity and heat stress, showing improved biomass, ion balance, chlorophyll content, and antioxidant enzyme activity, potentially enhancing crop tolerance to environmental stress.

In this study, researchers observed that acute stress increased levels of the enzyme 5αR2 in the medial prefrontal cortex of male rats, affecting stress reactivity, but this effect was not seen in females.

This study found that glycyrrhetinic acid, derived from licorice, may help alleviate acne symptoms by regulating lipid synthesis and inflammatory responses through multiple pathways, as observed in both in vitro and in vivo settings.

This study found that scoparone increased the expression of certain pluripotency-related proteins in dermal papilla cells, suggesting a potential new mechanism for enhancing hair growth.

This study suggests that women with polycystic ovary syndrome may have an increased risk of COVID-19-related cardiac and renal complications, and that weight loss through lifestyle changes could help reduce these risks.

This study found that chitosan nanoparticles containing Cordyceps militaris effectively reduced lung damage in mice exposed to fine particulate matter (PM2.5) by decreasing oxidative stress and preserving lung barrier integrity, suggesting potential as a therapeutic candidate for PM2.5-induced lung diseases.

In this study, pregnenolone was found to dose-dependently reduce L-DOPA-induced dyskinesias in a rat model of Parkinson's disease, suggesting its potential as a therapeutic target for these dyskinesias.

This study found that root hair length and density in rice are controlled by distinct genomic regions, with 18 regions identified but no overlap between the traits.