Follicular Fluid: A Powerful Tool for the Understanding and Diagnosis of Polycystic Ovary Syndrome

This document reviewed the use of human follicular fluid in metabolomic analysis as a diagnostic tool and predictor of success in assisted reproductive technology (ART) for patients with polycystic ovary syndrome (PCOS). PCOS affected 5% to 20% of women worldwide and was a leading cause of anovulatory infertility. Patients with PCOS undergoing ART often experienced poor to exaggerated responses, low oocyte quality, and other complications, leading to decreased success rates in various reproductive stages. The study highlighted the potential of metabolomic analysis in improving the accuracy of predicting ART outcomes by analyzing proteins and peptides in follicular fluid.