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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Neurosteroids show promise for treating epilepsy and more research is needed.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Finasteride helps protect brain in old male rats.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Skin changes can indicate hormonal imbalances and help diagnose endocrine disorders.

Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

Finasteride blocks progesterone's effect on absence seizures in rats.

Finasteride reduces response to stress and rewards, affecting behavior and mental health.

Post-finasteride patients show changes in gut bacteria, possibly causing various symptoms.

Isoallopregnanolone may be a safe and effective treatment for reducing tics in a mouse model of Tourette syndrome.

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

Stress and hormones like progesterone can affect absence seizures, but their effects change with different life stages.

Finasteride reduces sperm count and quality and alters hormone levels in mice.

Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

DHT, a testosterone byproduct, causes male pattern baldness.

Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.

Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.

New genes and pathways are important for testosterone production and male sexual development.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.