Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study suggests that the adrenal gland may contribute to prostate cancer treatment resistance and indicates potential steroid production or dependency in ovarian cancer.

This research focused on formulating finasteride, dutasteride, and minoxidil with cyclodextrins to enhance their solubility and skin penetration for topical use, potentially reducing scalp irritation from current alcohol-based preparations.

This study found a significant association between AGDAC measurements and the presence of PCOS, suggesting it could be an effective clinical tool in diagnosing the condition and its phenotypes, especially when combined with AMH.

This review discusses recent advancements in understanding and managing congenital adrenal hyperplasia, including improvements in screening, diagnostics, and potential genetic and cell-based treatments, but reports no new clinical findings.

This review identifies and discusses various endocrine-related causes of hypertension in children and adolescents, emphasizing the role of genetic predispositions and highlighting the need for systematic diagnostic guidelines and genetic sequencing referrals to improve diagnosis and treatment strategies.

In this review, the authors aim to improve the differential diagnosis between hyperandrogenic PCOS and NCAH, which could lead to more personalized treatment strategies for patients experiencing hyperandrogenism.

This study reported that while no synthesized compounds surpassed finasteride in 5α-reductase inhibitory activity, certain 4-azasteroid-2-oximes exhibited notable inhibition.

This study found that both declining levels of the neurosteroid THP and increasing levels of estradiol before puberty trigger maximal expression of α4βδ GABAA receptors in the CA1 hippocampus of female mice.

This study found that 11-oxygenated androgens were higher in women with PCOS compared to those with idiopathic hirsutism, with no difference from controls, and higher Bisphenol A levels in obese women with PCOS may worsen metabolic issues.

This review discusses the role of skin enzymes in drug metabolism and emphasizes the need for models assessing enzyme activity to evaluate the safety and bioequivalence of topical generic drugs, highlighting efforts to standardize testing protocols for transdermal products.

This study highlighted the promising health benefits of taxifolin, a flavonoid with antioxidant, anti-inflammatory, and other protective effects found in foods like onions and milk thistle, though more research is needed to fully understand its mechanisms and safety for human therapeutic use.

This study identified distinct differences in metabolic pathways related to pattern baldness, with findings highlighting the androgen metabolic pathway in males and the estrogen plus arachidonic acid pathways in females using hair samples.

The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.

This review examines patents and publications on steroid sulfatase inhibitors since 1999 and reports no new clinical results, highlighting their potential for treating estrogen- and androgen-driven conditions.

This study found that progesterone significantly delayed epileptogenesis development in a mouse model, and its effects were inhibited by finasteride, highlighting the potential role of neurosteroids in modifying epilepsy progression.

This case report emphasizes the importance of recognizing non-classic congenital adrenal hyperplasia as a cause of hyperandrogenism and the need for genetic counseling given potential familial implications.

This article discusses the various roles of steroids in vertebrate organ systems and notes several glucocorticoids that were among the Top 200 Drugs by sales in the 2010s, but it reports no new clinical findings.

This study reported that certain newly synthesized steroidal derivatives showed stronger inhibitory activity against the 5α-reductase enzyme than finasteride in hamsters, suggesting their potential as enzyme inhibitors.

This review discusses the complex etiology of polycystic ovary syndrome (PCOS), highlighting its association with insulin resistance and hyperandrogenism, but reports no clinical findings; the authors suggest further investigation of the pathophysiological mechanisms.

This review discusses the potential role of steroid 5α-reductase inhibitors in treating neuropsychiatric disorders related to dopaminergic hyperreactivity but reports no new clinical results.

This article reviews the characteristics and classification of SAHA syndrome and its relationship with other conditions, without presenting new clinical findings.

This article reviews assessment and management strategies for adolescent females with excessive hair growth and highlights the importance of evaluating potential androgen sources.

This study found that treatment with the pure antiandrogen Flutamide did not affect the estrous cycle or plasma levels of most hormones in female rats, supporting its potential use for treating hirsutism, acne, and alopecia in women.

This review discusses the unique challenges of diagnosing and managing polycystic ovarian syndrome in adolescents and reports no new clinical findings.

This review suggests that GABAergic neuroactive steroids modulated by alcohol could play a role in vulnerability to alcohol use disorders, providing a rationale for further therapeutic exploration.

Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.

This review explores finasteride's effects on neuroactive steroid levels and their potential influence on disorders like depression and alcohol withdrawal but reports no new clinical findings.

This study found trilostane to be an effective and generally safe treatment for improving symptoms in dogs with pituitary-dependent hyperadrenocorticism.

This article examines current pharmacologic treatments for PCOS focusing on symptom-specific approaches, particularly the metabolic effects of therapies, but reports no new clinical findings.

This review examines the role of cyclodextrins in improving the solubility, stability, and bioavailability of steroid drugs but does not report new experimental findings.