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    Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System

    Aditya K. Gupta, Mesbah Talukder, Sharon A. Keene, Mary A. Bamimore
    Studysummary In this study, analysis of FDA adverse event reports revealed that topical finasteride was associated with fewer post-finasteride syndrome-like adverse events than oral finasteride, but many reports lack critical data, suggesting caution in attributing causality.
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    Research cited in this study 16

    1. Randomized Controlled Trial on the Efficacy and Safety of the Combination Therapy of Topical 0.1% Finasteride and 5% Minoxidil in Male Androgenetic Alopecia Archives of Dermatological Research · 2025
    2. Efficacy and Safety of Topical Finasteride Spray Solution in the Treatment of Chinese Men with Androgenetic Alopecia: A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Chinese Medical Journal · 2025
    3. The Pharmacokinetics of Topical Finasteride 0.25% Spray in Chinese Adult Male Volunteers with Androgenic Alopecia: A Phase I Study Advances in Therapy · 2025
    4. Painful Bilateral Gynecomastia Secondary to Topical Finasteride Australasian Journal of Dermatology · 2024
    5. Patient-Reported Outcomes of Topical Finasteride/Minoxidil Treatment for Male Androgenetic Alopecia: A Retrospective Study Using Telemedical Data Journal of cosmetic dermatology · 2024
    6. Factors Associated With Early-Onset Androgenetic Alopecia: A Scoping Review PLOS ONE · 2024
    7. The Role of Topical Finasteride in Hair Loss Management: Current Evidence and Future Perspectives International Journal of Biomedicine · 2023
    8. Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia Journal of Dermatological Treatment · 2022
    9. Mesotherapy With Dutasteride for Androgenetic Alopecia: A Retrospective Study in Real Clinical Practice PubMed · 2022
    10. Topical Finasteride for Male and Female Pattern Hair Loss: Is It a Safe and Effective Alternative? Journal of Cosmetic Dermatology · 2022
    11. Association Between Psychosocial Distress, Sexual Disorders, Self-Esteem, and Quality of Life With Male Androgenetic Alopecia: A Population-Based Study With Men at Age 46 BMJ Open · 2021
    12. How Routine Pharmacovigilance Failed to Identify Finasteride’s Persistent Sexual Side Effects International Journal of Andrology · 2021
    13. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    14. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    15. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007
    16. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004

    Related research 6

    1. Phytotherapeutic Alternatives to the Use of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors in the Treatment of Androgenetic Alopecia: A Review Brazilian Journal of Hair Health · 2024
    2. Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair Clinica Chimica Acta · 2023
    3. What Do We Know About 5-Alpha Reductase Inhibitors? Surgical and Cosmetic Dermatology · 2018
    4. Dutasteride in Androgenetic Alopecia: An Update Current Clinical Pharmacology · 2017
    5. Dutasteride for Men with Androgenic Alopecia Unresponsive to Finasteride Journal of Investigative Dermatology · 2016
    6. The Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice The FASEB Journal · 2013