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    Evaluation of the Cosmetic Efficacy of Salmon Tissue-Derived Exosomes and Plasmatherapy in Patients with Androgenetic Alopecia: A Randomized Controlled Clinical Trial

    May 2026 in “ Russian Journal of Skin and Venereal Diseases ”
    Olga Olisova, Vera Smolyannikova, Karim Karray, Anfisa Lepekhova
    Studysummary This study found that salmon tissue-derived exosomes showed significantly greater improvements in hair density and other parameters compared to platelet-rich plasma in patients with mild to moderate androgenetic alopecia.
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    Research cited in this study 17

    1. Exosomes And Hair Regeneration: A Systematic Review Of Clinical Evidence Across Alopecia Types And Exosome Sources Clinical Cosmetic and Investigational Dermatology · 2025
    2. Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment Drug Design Development and Therapy · 2025
    3. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway Stem Cell Research & Therapy · 2025
    4. Platelet-Rich Plasma-Derived Exosomes Stimulate Hair Follicle Growth Through Activation of the Wnt/β-Catenin Signaling Pathway Regenerative Therapy · 2025
    5. A Pilot Randomized Controlled Trial Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia Life · 2025
    6. Exploring the Efficacy and Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Androgenic Alopecia 2024
    7. The Role of Exosomes in the Diagnosis and Treatment of Immune Mediated Dermatosis, Treatment of Skin Wounds and Alopecia Vestnik dermatologii i venerologii · 2024
    8. Diagnosis and Differential Diagnosis of Tertiary Androgenetic Alopecia With Severe Alopecia Areata Based on High-Resolution MRI Skin Research and Technology · 2023
    9. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    10. Hair Regrowth Treatment Efficacy and Resistance in Androgenetic Alopecia: A Systematic Review and Continuous Bayesian Network Meta-Analysis Frontiers in Medicine · 2023
    11. Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways Frontiers in Medicine · 2022
    12. Association Between Androgenetic Alopecia and Psychosocial Disease Burden: A Cross-Sectional Survey Among Polish Men Dermatology Research and Practice · 2022
    13. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    14. An Appraisal of Laboratory Models of Androgenetic Alopecia: A Systematic Review Skin health and disease · 2021
    15. Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia International Journal of Molecular Sciences · 2020
    16. Cross-Sectional Quality of Life Assessment in Patients with Androgenetic Alopecia Dermatologic Therapy · 2020
    17. Stromal Vascular Fraction-Enriched Platelet-Rich Plasma Therapy Reverses the Effects of Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019