Co-Factors of LIM Domains (Clims/Ldb/Nli) Regulate Corneal Homeostasis and Maintenance of Hair Follicle Stem Cells

    October 2007 in “ Developmental biology ”
    Xiaoman Xu, Jaana Männik, Elena Kudryavtseva … Bogi Andersen
    Studysummary In this study, transgenic mice altered to express a Clim-inhibiting molecule under a keratin promoter showed corneal degradation and hair follicle failure, highlighting Clim proteins' role in maintaining these tissues.
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    Research cited in this study 8

    1. Transdifferentiation of Corneal Epithelium Into Epidermis Occurs by Means of a Multistep Process Triggered by Dermal Developmental Signals Proceedings of the National Academy of Sciences · 2005
    2. Transdifferentiation of Corneal Epithelium: Evidence for a Linkage Between the Segregation of Epidermal Stem Cells and the Induction of Hair Follicles During Embryogenesis The International Journal of Developmental Biology · 2004
    3. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    4. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    5. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    6. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001
    7. Conditional Expression of the ErbB2 Oncogene Elicits Reversible Hyperplasia in Stratified Epithelia and Up-Regulation of TGFα Expression in Transgenic Mice Oncogene · 1999
    8. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986

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    4. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    5. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    6. Skin-Specific Expression of a Truncated E1a Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation The Journal of Cell Biology · 1993
    7. Keratin Phenotypes in Basal-Cell Carcinomas of the Skin International Journal of Oncology · 1993
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