Keratin Phenotypes in Basal-Cell Carcinomas of the Skin

March 1993 in “ International Journal of Oncology ”

Airo Tsubura, Tatsuki Oyaizu, Yohei Fujita, Masahito Asada, Jan Oort Jo Hilgers, S Morii

basal cell carcinoma keratin keratin 14 keratin 17 keratin 1 immunohistochemical profiles pilosebaceous apparatus

TLDR Basal cell carcinoma shows keratin patterns similar to hair follicle structures.

The study examined the immunohistochemical profiles of 23 cases of basal cell carcinoma (BCC) and compared them with adjacent normal skin using three keratin antibodies. In normal skin, different keratins were expressed in specific skin structures, while in BCC, keratin 14 and 17 were consistently found in all cases, and keratin 1 was sporadically expressed in 3 cases. The findings suggested that the keratin expression in BCC resembled that of the pilosebaceous apparatus.

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