The role of 5-α-reductase inhibition in supressing progression of male androgenetic alopecia − a postulate for further studies on possible application of saw palmetto extracts

    Marcin Piwecki, Alicia L. Urban, Jolanta Pełszyńska
    TLDR Saw palmetto extracts might help treat male hair loss and need more research.
    The document discusses the role of the enzyme 5-α-reductase in male androgenetic alopecia (MAGA), which disrupts hair follicle nourishment and accelerates the transition from the anagen to the catagen phase of hair growth by converting testosterone into dihydrotestosterone (DHT). The study suggests that inhibitors can target this enzyme and proposes further research into the effects of saw palmetto extracts, specifically stigmasterol and β-sitosterol, due to their inhibitory activity. It also advocates for investigating the impact of saw palmetto extract on the hair growth cycle, hair follicle life cycle, various growth factors and angiogenesis, immune system activity, and oxidative stress.
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