PCA: A TFNA-Based Targeted Nucleic Acid Nanocomposite Hydrogel for the Treatment of Androgenetic Alopecia Through the Promotion of Angiogenesis and Hair Follicle Stem Cell Proliferation

    February 2026 in “ Chemical Engineering Journal ”
    Dan Zhao, Meiying Shao, Yunfeng Lin
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    Studysummary This study found that a novel nano-engineered platform, PCA, significantly promoted hair regeneration in an androgenetic alopecia mouse model by enhancing angiogenesis and hair follicle stem cell proliferation, showing promise for future hair regrowth treatments. Our plain-language summary of this paper — not a Tressless recommendation.
    The study introduces PCA, a novel tFNA-based targeted nanocomposite hydrogel, for treating androgenetic alopecia (AGA) by enhancing angiogenesis and hair follicle stem cell proliferation. PCA facilitates sustained delivery of the therapeutic complex Apt02-tFNA-miR210 (ATM). In an AGA mouse model, PCA significantly promoted hair regeneration by activating VEGF and Wnt/β-catenin signaling pathways, increasing blood vessel formation, and stimulating hair follicle stem cells. This approach overcomes current AGA treatment limitations, showing promise as a safe and effective nanotherapeutic strategy for hair loss.
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