PCA: A TFNA-Based Targeted Nucleic Acid Nanocomposite Hydrogel for the Treatment of Androgenetic Alopecia Through the Promotion of Angiogenesis and Hair Follicle Stem Cell Proliferation

    February 2026 in “ Chemical Engineering Journal ”
    Dan Zhao, Meiying Shao, Yunfeng Lin
    Studysummary This study found that a novel nano-engineered platform, PCA, significantly promoted hair regeneration in an androgenetic alopecia mouse model by enhancing angiogenesis and hair follicle stem cell proliferation, showing promise for future hair regrowth treatments.
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    Research cited in this study 15

    1. Comparative Efficacy and Safety of Low-Level Laser Therapy and Topical Minoxidil Combination vs. Topical Minoxidil Monotherapy in Androgenetic Alopecia Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Lasers in Medical Science · 2025
    2. Shen-Ying-Yang-Zhen Formula Promotes Angiogenesis Around Hair Follicles, Alleviates Oxidative Stress, and Inhibits Hair Follicle Apoptosis Through the VEGF/Akt/Caspase-9 Signaling Axis Phytomedicine · 2025
    3. Application of Platelet-Rich Plasma Lysate Combined with Hyaluronic Acid Microneedles for the Treatment of Alopecia Drug Delivery and Translational Research · 2025
    4. Androgenetic Alopecia: Therapy Update Drugs · 2023
    5. Global Online Interest in Finasteride Sexual Side Effects International Journal of Impotence Research · 2022
    6. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    7. Non-Thermal Plasma Promotes Hair Growth by Improving the Inter-Follicular Macroenvironment RSC Advances · 2021
    8. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    9. Characterization of Human Dermal Sheath Cells Reveals CD36-Expressing Perivascular Cells Associated with Capillary Blood Vessel Formation in Hair Follicles Biochemical and Biophysical Research Communications · 2019
    10. Androgenetic Alopecia: A Review Endocrine · 2017
    11. Female Pattern Hair Loss: A Clinical and Pathophysiological Review Anais Brasileiros De Dermatologia · 2015
    12. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    13. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    14. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    15. Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles Journal of Investigative Dermatology · 1995