Taurine Alleviates Androgenetic Alopecia in Male C57BL/6 Mice by Modulating Hair Follicle Cycle and Related Signaling Pathways

    November 2025 in “ PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS ”
    Jin-Qiang WU, Guo-Guo GUO, Xin-Ting Zhang, Jin-jia LIU, Ji Xiang Wang, Xiao Yan He, Hai-dong Wang
    TLDR Taurine may help reduce hair loss by improving hair growth cycles.
    This study investigates the effects of taurine on dihydrotestosterone (DHT)-induced androgenetic alopecia (AGA) in male C57BL/6 mice. Taurine was found to significantly alleviate AGA by promoting the transition from the telogen to anagen phase of the hair follicle cycle, enhancing keratinocyte proliferation, reducing apoptosis, and downregulating the expression of androgen receptor (AR), TGF-β1, TGF-β2, and DKK1. These effects were particularly notable at higher doses of taurine. The study suggests that taurine, with its favorable safety profile and multi-targeted action, could be a promising therapeutic candidate for AGA, warranting further clinical investigation.
    Discuss this study in the Community →

    Research cited in this study

    25 / 25 results

    Related Community Posts Join

    6 / 46 results

      community 1% cetirizine (available in allergy medicines) for androgenetic alopecia

       49 upvotes 6 years ago
      The conversation discusses using 1% cetirizine, an antihistamine, as a potential treatment for androgenetic alopecia (hair loss). One user plans to try cetirizine instead of finasteride, while others are curious or skeptical about its effectiveness, discussing the role of inflammation in hair loss.

      community Minoxidil actually reduces wrinkles

      in Research/Science  209 upvotes 1 year ago
      Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

      community "DHT Itch" and onset Seborrheic Dermatitis

      in Research/Science  76 upvotes 2 years ago
      The post and conversation discuss the link between DHT (a hormone), scalp itchiness, and hair loss. Some users share their experiences and treatments, including the use of fluconazole, corticosteroids, and ketoconazole shampoo, with one user suspecting minoxidil as a potential cause of their symptoms.

    Similar Research

    5 / 187 results