Tacrolimus Ointment: Summarizing Two Decades of Experience in Off-Label Use. Use in Rosacea, Seborrheic Dermatitis, Papulosquamous Dermatoses, Lupus Erythematosus, Eczematous Dermatoses, Alopecia, and Other Diseases

    January 2026 in “ Vestnik dermatologii i venerologii ”
    D. D. Petrunin
    Studysummary In this review, the authors report that tacrolimus ointment shows promise for expanding its use to a variety of skin conditions, beyond its current approval for atopic dermatitis, by analyzing clinical experiences of its application for rosacea, seborrheic dermatitis, psoriasis, and other dermatoses.
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    Research cited in this study 10

    1. Frontal Fibrosing Alopecia Part II: Etiopathogenesis and Management Journal of the American Academy of Dermatology · 2025
    2. Fractionated CO2 Laser in Combination with Topical Tacrolimus for Chronic Alopecia Areata: A Case Series Study Life · 2024
    3. Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions Frontiers in immunology · 2023
    4. Alopecia Areata: Current Treatments and New Directions American Journal of Clinical Dermatology · 2023
    5. Comparative Evaluation of the Efficacy of Topical Tacrolimus 0.03% and Topical Calcipotriol 0.005% Mixed With Betamethasone Dipropionate Versus Topical Clobetasol 0.05% in Treatment of Alopecia Areata: A Clinical and Trichoscopic Study Journal of cosmetic dermatology · 2022
    6. Evaluating the Combined Efficacy of Oral Isotretinoin and Topical Tacrolimus Versus Oral Finasteride and Topical Tacrolimus in Frontal Fibrosing Alopecia: A Randomized Controlled Trial Journal of Cosmetic Dermatology · 2022
    7. Oral Isotretinoin Combined with Topical Clobetasol 0.05% and Tacrolimus 0.1% for the Treatment of Frontal Fibrosing Alopecia: A Randomized Controlled Trial Journal of Dermatological Treatment · 2020
    8. Randomized Comparison of Topical Betamethasone Valerate Foam, Intralesional Triamcinolone Acetonide, and Tacrolimus Ointment in Management of Localized Alopecia Areata International journal of trichology · 2011
    9. Lack of Response of Alopecia Areata to Pimecrolimus Cream Clinical and experimental dermatology · 2007
    10. Topical Tacrolimus (FK506): Treatment Failure in Four Cases of Alopecia Universalis Acta dermato-venereologica · 2002