TLDR Topical tacrolimus is safe and effective for skin conditions, but oral tacrolimus has serious side effects.
The document reviewed the use of tacrolimus for various skin disorders, finding that topical tacrolimus was a safe and effective short-term treatment for conditions like atopic dermatitis and mucosal lichen planus. Oral tacrolimus was effective for recalcitrant plaque psoriasis but had severe adverse effects, including infections and nephrotoxicity. Further studies were recommended to assess long-term safety and optimal dosage.
22 citations,
January 2012 in “Mediators of inflammation” Nonantibiotic macrolides show promise for treating various inflammatory skin conditions.
13 citations,
August 2020 in “Mayo Clinic proceedings” Women with lichen planopilaris often have thyroid disease, depression, anxiety, and may respond to treatment with slowed disease progression.
April 2023 in “Dermatology practical & conceptual” Tacrolimus solution is effective and well-tolerated for treating inflammatory scalp conditions.
59 citations,
June 2022 in “Frontiers in medicine” There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
25 citations,
December 2017 in “Facial Plastic Surgery” Combination therapy with steroids and pimecrolimus improved or stabilized hair loss in most patients with Frontal Fibrosing Alopecia, who also had a high rate of hypothyroidism.
