Efficacy of Oral Apremilast in the Treatment of Alopecia Areata at the Tertiary Care Hospital, Karachi

December 2023 in “ Journal of health and rehabilitation research ”

Parisa Sanawar, Rabia Ghafoor, Khusru Asadullah, Nusrat Jabeen, Farhan Ahmed Siddiqui, Misbah Qadir

oral Apremilast alopecia areata Severity of Alopecia Tool SALT scores Apremilast

TLDR Oral Apremilast effectively treats alopecia areata in most patients.

The study conducted at Jinnah Postgraduate Medical Centre in Karachi assessed the efficacy of oral Apremilast in treating alopecia areata (AA) in 85 patients. Administered at 30 mg twice daily, Apremilast significantly reduced the Severity of Alopecia Tool (SALT) scores from 62.42 to 41.53 over 12 weeks, with a mean difference of 20.89 (p-value: 0.0001). The treatment was effective in 80% of patients, suggesting that oral Apremilast could be a promising alternative for AA treatment, warranting further clinical investigation.

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