Efficacy of Oral Apremilast in the Treatment of Alopecia Areata at the Tertiary Care Hospital, Karachi

December 2023 in “ Journal of health and rehabilitation research ”

Parisa Sanawar, Rabia Ghafoor, Khusru Asadullah, Nusrat Jabeen, Farhan Ahmed Siddiqui, Misbah Qadir

oral Apremilast alopecia areata Severity of Alopecia Tool SALT scores Apremilast

TLDR Oral Apremilast effectively treats alopecia areata in most patients.

The study conducted at Jinnah Postgraduate Medical Centre in Karachi assessed the efficacy of oral Apremilast in treating alopecia areata (AA) in 85 patients. Administered at 30 mg twice daily, Apremilast significantly reduced the Severity of Alopecia Tool (SALT) scores from 62.42 to 41.53 over 12 weeks, with a mean difference of 20.89 (p-value: 0.0001). The treatment was effective in 80% of patients, suggesting that oral Apremilast could be a promising alternative for AA treatment, warranting further clinical investigation.

View this study on jhrlmc.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community 2020 Hair and Scalp Treatments: A Clinical Guide (in Depth 350 Page Guide)

in Treatment 64 upvotes 4 years ago

Treatments for hair loss, including topical immunotherapy, regenerative treatments, laser and light-based therapies, oral supplements, intralesional steroids, and new drugs like finasteride and minoxidil.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 3 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Oral Min 2.5mg, oral fin 1mg, 2mm derma roller, discouraged by results after a month

in Journals / Progress Pictures 79 upvotes 6 days ago

The user is using oral Minoxidil 2.5 mg, oral Finasteride 1 mg, and a 2mm derma roller for hair loss but feels discouraged by the lack of results after a month. They are seeking advice and considering additional methods like antiandrogens, exercise, and dietary changes.

community How Dangerous is Oral Min Really?

in Minoxidil 26 upvotes 1 week ago

Oral minoxidil is generally effective for hair loss but may cause side effects like heart palpitations and facial puffiness. Users highlight the importance of monitoring blood pressure due to potential cardiovascular risks.

community Oral minoxidil + microneedling - pointless?

in Microneedling 19 upvotes 2 weeks ago

Oral minoxidil is considered effective for hair growth, and some users combine it with microneedling despite mixed opinions on its additional benefits. Concerns about microneedling include potential scarring and lack of conclusive evidence on its effectiveness when used with oral treatments.

community Oral Dutasteride before vs After !

in Finasteride/Dutasteride 75 upvotes 3 weeks ago

A 27-year-old male experienced hair thickening using a specialized pill containing Dutasteride and Minoxidil, despite taking it irregularly due to being away from home. He plans to resume a more regular dosing schedule for better results, as he noticed side effects like brain fog and decreased libido.

Related Research

1 / 1 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.