Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp

A case series involving 22 patients (aged 24-90) with various inflammatory scalp conditions (lichen planus pilaris, discoid lupus, frontal fibrosing alopecia, erosive pustulosis of the scalp, and folliculitis decalvans) demonstrated that topical tacrolimus solution (0.1%) applied twice daily for 1 month, then once daily for another month, and on alternate days for 4 months, was effective and well-tolerated. After 1 month, 63.6% of patients showed a good response and 31.8% an excellent response. After 2 months, 72.7% had an excellent response, which persisted after 6 months, suggesting tacrolimus solution as a promising maintenance treatment for these conditions.